Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, U.S.A.
Adipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, U.S.A.
Clin Sci (Lond). 2020 Mar 27;134(6):629-639. doi: 10.1042/CS20190522.
Adipocytes and adipose tissue are not inert and make substantial contributions to systemic metabolism by influencing energy homeostasis, insulin sensitivity, and lipid storage. In addition to well-studied hormones such as insulin, there are numerous hormones, cytokines, and growth factors that modulate adipose tissue function. Many endocrine mediators utilize the JAK-STAT pathway to mediate dozens of biological processes, including inflammation and immune responses. JAKs and STATs can modulate both adipocyte development and mature adipocyte function. Of the seven STAT family members, four STATs are expressed in adipocytes and regulated during adipogenesis (STATs 1, 3, 5A, and 5B). These STATs have been shown to play influential roles in adipose tissue development and function. STAT6, in contrast, is highly expressed in both preadipocytes and mature adipocytes, but is not considered to play a major role in regulating adipose tissue function. This review will summarize the latest research that pertains to the functions of STATs in adipocytes and adipose tissue.
脂肪细胞和脂肪组织并非惰性的，它们通过影响能量平衡、胰岛素敏感性和脂质储存，对全身代谢做出实质性贡献。除了胰岛素等研究充分的激素外，还有许多激素、细胞因子和生长因子调节脂肪组织功能。许多内分泌介质利用 JAK-STAT 途径来介导包括炎症和免疫反应在内的数十种生物学过程。JAK 和 STAT 可以调节脂肪细胞的发育和成熟脂肪细胞的功能。在七个 STAT 家族成员中，有四个 STAT 在脂肪生成过程中表达并受到调节（STATs 1、3、5A 和 5B）。这些 STAT 已被证明在脂肪组织发育和功能中发挥重要作用。相比之下，STAT6 在脂肪前体细胞和成熟脂肪细胞中均高度表达，但不被认为在调节脂肪组织功能中起主要作用。本综述将总结与 STAT 在脂肪细胞和脂肪组织中的功能相关的最新研究。
