Department of Digestive Diseases and Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Pancreas. 2011 Aug;40(6):938-45. doi: 10.1097/MPA.0b013e318216f693.
The objective of the study was to evaluate clinical features and quality of life (QoL) in a 2-year follow-up study in subjects who underwent pancreatic head resection (PHR).
One hundred ninety-seven patients with benign and malignant diseases who underwent PHR were studied. A dedicated clinical form and the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire C-30 were administered at evaluation times (immediately before surgery and 6, 12, 18, and 24 months after discharge). A sample of 197 sex- and age-matched norms was also included into the study as reference group.
Of the 197 patients studied, 164 (83.2%) had malignant disease, and 33 had benign disease (16.8%). At initial evaluation, global health was significantly lower (P = 0.001) in the study population as compared with the norms. At the end of the study, the QoL was not significantly different from the norms, although the QoL of the 30 patients with benign disease was significantly better than that of the 72 patients with malignant disease.
The QoL before PHR was impaired in study patients before resection as compared with the normative population, whereas in patients who survived resection, it significantly improved in the 24 months after surgery.
本研究旨在评估接受胰头切除术（PHR）的患者在 2 年随访期的临床特征和生活质量（QoL）。
研究纳入了 197 例患有良性和恶性疾病并接受 PHR 的患者。在评估时间（手术前、出院后 6、12、18 和 24 个月）使用专门的临床表格和欧洲癌症研究与治疗组织生活质量问卷 C-30 进行评估。还纳入了 197 名性别和年龄匹配的正常人为参考组。
在研究的 197 例患者中，164 例（83.2%）患有恶性疾病，33 例患有良性疾病（16.8%）。在初始评估时，与正常人群相比，研究人群的总体健康状况明显较差（P=0.001）。在研究结束时，与正常人群相比，QoL 没有显著差异，尽管 30 例良性疾病患者的 QoL 明显优于 72 例恶性疾病患者。
与正常人群相比，接受 PHR 前的研究患者的 QoL 受损，而在接受手术切除后存活的患者中，术后 24 个月 QoL 显著改善。
