靶向纳米探针通过时间分辨 MRI 揭示体内早期时间点动力学。
Targeted nanoprobes reveal early time point kinetics in vivo by time-resolved MRI.
机构信息
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892.
出版信息
Theranostics. 2011 Apr 26;1:274-6. doi: 10.7150/thno/v01p0274.
Abstract
This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T(2)*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes.
摘要
这篇评论强调了 Kessinger 等人的研究结果（Theranostics 2011；1:263-275），即动态 T(2)*加权磁共振成像（MRI）对环状 RGD 肽编码超顺磁聚合物胶束（SPPM）纳米粒子的研究，可以对肿瘤整联蛋白 αvβ3 的表达进行定量分析，从而排除了血液体积和血管外信号成分的影响，因此提供了更具偏差的肿瘤对比度和探针的受体特异性。
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