Department of Neurology, Kangwon National University Hospital, Chuncheon, South Korea.
Neurol Sci. 2012 Feb;33(1):45-51. doi: 10.1007/s10072-011-0617-1. Epub 2011 May 12.
Previous reports have shown that cigarette smoking is associated with white matter hyperintensities (WMHs). However, it remains unclear whether this is true for all ages. We investigated the association between cigarette smoking, WMHs, and age. We retrospectively reviewed charts from 595 patients, who presented as outpatients from January 2007 to March 2010. Grading of periventricular WMHs (PVWMHs) and the scores of deep WMHs (DWMHs) was determined based on criteria established by the Rotterdam Scan Study. We compared the degree of WMHs between smokers and non-smokers, and those younger than the age of 65 years versus those above. In younger age group, smokers had higher grades of PVWMHs and more microbleeds than non-smokers. In the older age group, total burden of DWMHs was much greater in smokers than nonsmokers. Multivariate regression analysis showed that cigarette smoking was an independent risk factor for PVWMHs in the younger age group and for DWMHs in the older age group. The location of WMHs in association with smoking seems to differ among age groups. Age should be considered when interpreting the effects of smoking on the brain.
先前的报告表明，吸烟与脑白质高信号（WMHs）有关。然而，目前尚不清楚这是否适用于所有年龄段。我们研究了吸烟、WMHs 和年龄之间的关系。我们回顾了 2007 年 1 月至 2010 年 3 月期间作为门诊患者就诊的 595 名患者的图表。根据鹿特丹扫描研究制定的标准，对脑室周围 WMH（PVWMHs）的分级和深部 WMH（DWMHs）的评分进行了评估。我们比较了吸烟者和非吸烟者之间以及年龄小于 65 岁者与大于 65 岁者之间 WMH 的严重程度。在年龄较小的组中，吸烟者的 PVWMHs 分级较高，微出血也比不吸烟者多。在年龄较大的组中，吸烟者的深部WMHs 总负荷明显大于不吸烟者。多变量回归分析显示，吸烟是年轻组中 PVWMHs 的独立危险因素，也是老年组中 DWMHs 的独立危险因素。与吸烟相关的 WMH 部位在不同年龄组之间似乎存在差异。在解释吸烟对大脑的影响时，应考虑年龄因素。
