Okuno T, Higashi K, Shiraki K, Yamanishi K, Takahashi M, Kokado Y, Ishibashi M, Takahara S, Sonoda T, Tanaka K
Department of Virology, Osaka University, Japan.
Transplantation. 1990 Mar;49(3):519-22. doi: 10.1097/00007890-199003000-00009.
The relationship between renal transplantation and human herpesvirus 6 (HHV-6) infection was studied. All 21 kidney donors examined had antibody to HHV-6 at the time of transplantation. The 21 kidney recipients also had detectable antibody to HHV-6 before transplantation--and, of these, 8 patients showed a significant increase of serum antibody titer against HHV-6 after transplantation. All these 8 recipients suffered severe kidney rejection. Furthermore, virus isolation from peripheral blood lymphocytes of 2 recipients who suffered rejection was attempted, and in both cases HHV-6 was isolated. Biopsy specimens of rejected kidneys of 9 other patients were examined for the presence of HHV-6 antigens, and in 5 of these specimens antigens were detected in the tubular epithelium, as well as in infiltrating histiocytes and lymphocytes. These results suggest that HHV-6 can infect renal tissues and that the infection may be correlated with rejection or with immunosuppressive therapy.
对肾移植与人类疱疹病毒6型（HHV - 6）感染之间的关系进行了研究。所有接受检查的21名肾脏供体在移植时均有抗HHV - 6抗体。这21名肾脏受体在移植前也检测到了抗HHV - 6抗体，其中8名患者在移植后血清抗HHV - 6抗体滴度显著升高。这8名受体均遭受了严重的肾排斥反应。此外，尝试从2名发生排斥反应的受体的外周血淋巴细胞中分离病毒，在这两例中均分离出了HHV - 6。对另外9名患者被排斥肾脏的活检标本进行了HHV - 6抗原检测，在其中5份标本的肾小管上皮细胞以及浸润的组织细胞和淋巴细胞中检测到了抗原。这些结果表明，HHV - 6可感染肾组织，且这种感染可能与排斥反应或免疫抑制治疗有关。
