Lautenschlager I, Höckerstedt K, Linnavuori K, Taskinen E
Department of Virology, Helsinki University Central Hospital, Finland.
Clin Infect Dis. 1998 Mar;26(3):702-7. doi: 10.1086/514592.
A diagnosis of posttransplantation human herpesvirus-6 (HHV-6) infection was established for eight adult recipients among a liver transplantation patient population of 121. The diagnosis was based on serology and demonstration of HHV-6 specific antigens in liver biopsy specimens with use of monoclonal antibodies and immunoperoxidase staining. A significant graft dysfunction was recorded in association with serodiagnosis. HHV-6 early antigens, as well as HHV-6 variant B antigens, were detected retrospectively in all six available liver biopsy specimens. Histologic examination of biopsy specimens demonstrated acute rejection in 5 of the 8 patients, and 3 patients had portal lymphocyte infiltration. In five cases cytomegalovirus (CMV) infection was associated with HHV-6 infection; in four cases CMV antigens were also detected in the biopsy specimens. Two patients who had pure HHV-6 infection without CMV infection or rejection had significantly impaired graft function, with a positive antigen-detection test. Thus, HHV-6 may infect the liver allograft and cause graft dysfunction and may possibly be associated with rejection and/or CMV infection.
在121例肝移植患者群体中，有8名成年受者被确诊为移植后人类疱疹病毒6型（HHV-6）感染。该诊断基于血清学检查以及使用单克隆抗体和免疫过氧化物酶染色法在肝活检标本中证实存在HHV-6特异性抗原。记录到与血清学诊断相关的显著移植物功能障碍。在所有6份可用的肝活检标本中均回顾性检测到HHV-6早期抗原以及HHV-6 B型变体抗原。活检标本的组织学检查显示，8例患者中有5例发生急性排斥反应，3例患者有门静脉淋巴细胞浸润。5例患者的巨细胞病毒（CMV）感染与HHV-6感染相关；4例患者的活检标本中也检测到CMV抗原。2例单纯HHV-6感染且无CMV感染或排斥反应的患者，其移植物功能严重受损，抗原检测试验呈阳性。因此，HHV-6可能感染肝移植物并导致移植物功能障碍，还可能与排斥反应和/或CMV感染有关。
