College of Water Sciences, Beijing Normal University, Beijing 100875, China.
Biomed Environ Sci. 2011 Apr;24(2):132-9. doi: 10.3967/0895-3988.2011.02.007.
To measure the endocrine disrupting chemicals (EDCs) in wastewater and evaluate the EDCs removal efficiencies in the municipal wastewater treatment plants (WWTP).
A battery of in vitro recombinant yeast bioassays incorporated with exogenous metabolic activation system (rat liver preparation, S9 mix) was conducted to assess the estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), and thyroid receptor (TR) ant/agonistic activities of effluents collected from Datansha WWTP.
The indirect estrogenic, anti-androgenic, anti-progesteronic, and anti-thyroidic activities were observed in the influent. The removal efficiencies of EDCs were above 74%, suggesting that the present wastewater treatment processes were good enough to remove most of these indirect endocrine disrupting chemicals.
The incorporation of exogenous metabolic capacity into the test system was valid for the study of indirect effects on ER, AR, PR, and TR.
测定废水中的内分泌干扰化学物质（EDCs），并评估城市污水处理厂（WWTP）对 EDCs 的去除效率。
采用体外重组酵母生物测定法，并结合外源代谢活化系统（大鼠肝制备物、S9 混合物），评估从大船 WWTP 收集的废水对雌激素受体（ER）、雄激素受体（AR）、孕激素受体（PR）和甲状腺受体（TR）的拮抗/激动活性。
进水存在间接雌激素、抗雄激素、抗孕激素和抗甲状腺活性。EDCs 的去除效率高于 74%，表明目前的废水处理工艺足以去除大部分这些间接内分泌干扰化学物质。
在测试系统中加入外源代谢能力对于研究 ER、AR、PR 和 TR 的间接效应是有效的。
