Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
Am J Public Health. 2011 Dec;101(12):2333-41. doi: 10.2105/AJPH.2010.300068. Epub 2011 May 12.
To estimate the impact of the Integrated Management of Childhood Illness (IMCI) strategy on early-childhood mortality, we evaluated a malaria-control project in Benin that implemented IMCI and promoted insecticide-treated nets (ITNs).
We conducted a before-and-after intervention study that included a nonrandomized comparison group. We used the preceding birth technique to measure early-childhood mortality (risk of dying before age 30 months), and we used health facility surveys and household surveys to measure process indicators.
Most process indicators improved in the area covered by the intervention. Notably, because ITNs were also promoted in the comparison area children's ITN use increased by about 20 percentage points in both areas. Regarding early-childhood mortality, the trend from baseline (1999-2001) to follow-up (2002-2004) for the intervention area (13.0% decrease; P < .001) was 14.1% (P < .001) lower than was the trend for the comparison area (1.3% increase; P = .46).
Mortality decreased in the intervention area after IMCI and ITN promotion. ITN use increased similarly in both study areas, so the mortality impact of ITNs in the 2 areas might have canceled each other out. Thus, the mortality reduction could have been primarily attributable to IMCI's effect on health care quality and care-seeking.
为了评估综合儿童疾病管理(IMCI)战略对儿童早期死亡率的影响,我们评估了贝宁的一个疟疾控制项目,该项目实施了 IMCI 并推广了经杀虫剂处理的蚊帐(ITN)。
我们进行了一项干预前后的干预研究,包括一个非随机对照组。我们使用前出生技术来衡量儿童早期死亡率(30 个月前死亡的风险),并使用卫生机构调查和家庭调查来衡量过程指标。
干预覆盖地区的大多数过程指标都有所改善。值得注意的是,由于 ITN 也在对照组推广,两个地区儿童 ITN 使用量都增加了约 20 个百分点。关于儿童早期死亡率,干预地区的趋势从基线(1999-2001 年)到随访(2002-2004 年)下降了 13.0%(P<.001),比对照组的趋势低 14.1%(P<.001)(增加 1.3%;P=.46)。
在推广 IMCI 和 ITN 后,干预地区的死亡率下降。两个研究地区的 ITN 使用量都有相似的增加,因此 ITN 在这两个地区的死亡率影响可能相互抵消。因此,死亡率的降低可能主要归因于 IMCI 对医疗质量和寻求医疗的影响。