Federal Institute for Risk Assessment, Berlin, Germany.
Toxicol Lett. 2011 Jul 28;204(2-3):190-8. doi: 10.1016/j.toxlet.2011.04.032. Epub 2011 May 5.
New findings on Bisphenol A (BPA) contents in thermal printing papers, and receipts, in g/kg concentrations and on its dermal uptake (up to 60%) prompted us to assess the risk arising from dermal exposure. Using physiologically based toxicokinetic modelling, we simulated concentrations in blood, in liver and kidney, the target organs exhibiting the lowest no observed adverse effect levels (NOAEL). By comparing organ concentrations at the dose level of the NOAEL divided by a safety factor of 100 (liver: 50μg/kg/day; kidney: 500μg/kg/day), with concentrations arising from the dermal dose of 0.97μg/kg/day (worst case assumption by Biedermann et al., 2010) this dermal exposure can be assumed safe. Additionally, based on the model simulations the high blood concentrations, reported earlier in the literature, are highly improbable because the related exposure levels are orders of magnitude higher than the currently estimated aggregate exposure levels.
新发现热敏打印纸和收据中双酚 A（BPA）的含量以 g/kg 浓度计，以及其经皮吸收率（高达 60%），这促使我们评估经皮暴露所带来的风险。我们使用基于生理学的毒代动力学模型模拟了血液、肝脏和肾脏中的浓度，这些器官表现出最低的无观察到不良效应水平（NOAEL）。通过比较 NOAEL 剂量水平除以 100 安全系数（肝脏：50μg/kg/天；肾脏：500μg/kg/天）下的器官浓度与 0.97μg/kg/天的经皮剂量（Biedermann 等人，2010 年的最坏情况假设）产生的浓度，可假定这种经皮暴露是安全的。此外，基于模型模拟，文献中先前报道的高血液浓度极不可能，因为相关暴露水平比目前估计的总暴露水平高出几个数量级。
