家庭医生计划辅助下的巴西人群总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇的环境因素、家族聚集性和遗传性。

Environmental factors, familial aggregation and heritability of total cholesterol, low density lipoprotein-cholesterol and high density lipoprotein-cholesterol in a Brazilian population assisted by the Family Doctor Program.

机构信息

Department of Epidemiology and Biostatistics, Universidade Federal Fluminense, Niterói, Rio de Janeiro, RJ, Brazil.

出版信息

Public Health. 2011 Jun;125(6):329-37. doi: 10.1016/j.puhe.2011.02.009. Epub 2011 May 14.

DOI:10.1016/j.puhe.2011.02.009

PMID:21571348

Abstract

OBJECTIVES

To estimate familial aggregation and the heritability of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in families assisted by the Family Doctor Program in a Brazilian city, and to evaluate associations between some environmental factors and familial aggregation of these lipids.

STUDY DESIGN

Cross-sectional familial study.

METHODS

The association of lipids with sociodemographic factors, lifestyle factors and comorbidities (e.g. physical activity, alcohol consumption, smoking, hypertension, impaired glucose tolerance, body mass index) was estimated using linear models and generalized estimating equations. Correlation of TC, LDL-C and HDL-C between pairs of relatives was estimated with the familial correlation procedure, and heritability was estimated with the ASSOC procedure.

RESULTS

All associations were statistically significant. There was familial aggregation of TC (parent/offspring, r=0.33; sibling/sibling, r=0.37), LDL-C (parent/offspring, r=0.29; sibling/sibling, r=0.37) and HDL-C (parent/offspring, r=0.25; sibling/sibling, r=0.48), but less than 3%, 6% and 14%, respectively, which was explained by lifestyle factors. Correlation between pairs with genetic sharing (parent/offspring and sibling/sibling) was higher than that observed between father and mother. Heritability estimates ranged between 0.32 (HDL-C) and 0.50 (TC). Similar results were found for the two approaches used to estimate the contribution of genetic and environmental factors in the correlation of TC, LDL-C and HDL-C between the family pairs.

CONCLUSION

The results showed that there is familial aggregation of TC, LDL-C and HDL-C, and point to the predominance of genetic factors because little influence of environmental variables was found.

摘要

目的

利用家庭医生计划对巴西某城市的家庭进行评估，估计总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的家族聚集性及其遗传性，并评估环境因素与这些脂质的家族聚集性之间的关系。

研究设计

横断面家族研究。

方法

采用线性模型和广义估计方程评估脂质与社会人口统计学因素、生活方式因素和合并症（如身体活动、饮酒、吸烟、高血压、糖耐量受损、体重指数）之间的相关性。采用家族相关性程序估计 TC、LDL-C 和 HDL-C 之间亲属对之间的相关性，采用 ASSOC 程序估计遗传性。

结果

所有关联均具有统计学意义。TC（父母/子女，r=0.33；兄弟姐妹，r=0.37）、LDL-C（父母/子女，r=0.29；兄弟姐妹，r=0.37）和 HDL-C（父母/子女，r=0.25；兄弟姐妹，r=0.48）存在家族聚集性，但分别只有 3%、6%和 14%可以用生活方式因素来解释。具有遗传共享（父母/子女和兄弟姐妹）的亲属对之间的相关性高于父母之间的相关性。遗传率估计值在 0.32（HDL-C）至 0.50（TC）之间。两种方法都表明，遗传和环境因素对 TC、LDL-C 和 HDL-C 之间家族对相关性的贡献的估计结果相似。