Center for Learning and Memory, Department of Neurobiology, The University of Texas at Austin, 1 University Station Stop C7000, Austin, TX 78712, USA.
Curr Opin Neurobiol. 2011 Jun;21(3):467-74. doi: 10.1016/j.conb.2011.04.006. Epub 2011 May 14.
The hippocampus, a structure required for many types of memory, connects to the medial prefrontal cortex, an area that helps direct neuronal information streams during intentional behaviors. Increasing evidence suggests that oscillations regulate communication between these two regions. Theta rhythms may facilitate hippocampal inputs to the medial prefrontal cortex during mnemonic tasks and may also integrate series of functionally relevant gamma-mediated cell assemblies in the medial prefrontal cortex. During slow-wave sleep, temporal coordination of hippocampal sharp wave-ripples and medial prefrontal cortex spindles may be an important component of the process by which memories become hippocampus-independent. Studies using rodent models indicate that oscillatory phase-locking is disturbed in schizophrenia, emphasizing the need for more studies of oscillatory synchrony in the hippocampal-prefrontal network.
海马体是多种类型记忆所必需的结构，它与内侧前额叶皮质相连，后者有助于在有意行为中指导神经元信息流。越来越多的证据表明，振荡调节这两个区域之间的通信。θ节律可能有助于在记忆任务期间海马体输入到内侧前额叶皮质，也可能整合内侧前额叶皮质中一系列功能相关的γ介导的细胞集合。在慢波睡眠期间，海马体锐波和内侧前额叶皮质纺锤波的时间协调可能是记忆变得不依赖海马体的过程的一个重要组成部分。使用啮齿动物模型的研究表明，精神分裂症中振荡的相位锁定受到干扰，这强调了需要更多研究海马体-前额叶网络中的振荡同步。
