Harris Alexander Z, Gordon Joshua A
Department of Psychiatry, Columbia University, New York, New York 10032; email:
Annu Rev Neurosci. 2015 Jul 8;38:171-94. doi: 10.1146/annurev-neuro-071714-034111. Epub 2015 Apr 6.
Long-range synchrony between distant brain regions accompanies multiple forms of behavior. This review compares and contrasts the methods by which long-range synchrony is evaluated in both humans and model animals. Three examples of behaviorally relevant long-range synchrony are discussed in detail: gamma-frequency synchrony during visual perception, hippocampal-prefrontal synchrony during working memory, and prefrontal-amygdala synchrony during anxiety. Implications for circuit mechanism, translation, and clinical relevance are discussed.
远距离脑区之间的长程同步伴随着多种行为形式。本综述比较并对比了在人类和模式动物中评估长程同步的方法。详细讨论了行为相关长程同步的三个例子：视觉感知期间的伽马频率同步、工作记忆期间的海马-前额叶同步以及焦虑期间的前额叶-杏仁核同步。还讨论了对神经回路机制、转化研究及临床相关性的影响。
