Forsyth S, Penney P, Rooney G
Department of Sexual Health, Great Western Hospitals NHS Foundation Trust, Swindon, UK.
Int J STD AIDS. 2011 May;22(5):296-7. doi: 10.1258/ijsa.2009.009191.
A 40-year-old man who has sex with men (MSM) with urethral gonorrhoea failed to respond to treatment with 400 mg cefixime orally. Laboratory isolation of the post-treatment strain showed a minimum inhibitory concentration of ≥0.25 mg/L, which is a level of tolerance to cefixime that has not been previously documented in the UK. This case illustrates the importance of assessing all patients after treatment for gonorrhoea so that treatment failure and antibiotic resistance can be identified. It is vital that gonorrhoea culture continues to be attempted from all infected individuals to enable accurate diagnosis and antibiotic sensitivities. We also recommend that laboratories test for cefixime sensitivity routinely, given that it is one of the most commonly prescribed treatments for gonorrhoea.
一名患有尿道淋病的40岁男男性行为者（MSM）口服400毫克头孢克肟治疗无效。对治疗后菌株进行实验室分离显示最低抑菌浓度≥0.25毫克/升，这是英国此前未曾记录过的对头孢克肟的耐受水平。该病例说明了对所有淋病患者治疗后进行评估的重要性，以便能够识别治疗失败和抗生素耐药情况。对所有感染个体持续进行淋病培养以实现准确诊断和抗生素敏感性检测至关重要。鉴于头孢克肟是淋病最常用的处方治疗药物之一，我们还建议实验室常规检测其敏感性。
