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细胞分裂中的极光激酶 A:激酶活性并非必需。

Aurora A in cell division: kinase activity not required.

出版信息

Nat Cell Biol. 2011 Jun;13(6):638-9. doi: 10.1038/ncb2276. Epub 2011 May 15.

DOI:10.1038/ncb2276
PMID:21572422
Abstract

Aurora A kinase is a key regulator of cell division, whose functions were attributed to its ability to phosphorylate diverse substrates. Aurora A is now shown to have a kinase-independent role in the regulation of chromatin-mediated microtubule assembly.

摘要

极光激酶 A 是细胞分裂的关键调节因子,其功能归因于其磷酸化多种底物的能力。现在已经表明,极光激酶 A 在调节染色质介导的微管组装中具有激酶非依赖性作用。

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Aurora A in cell division: kinase activity not required.细胞分裂中的极光激酶 A:激酶活性并非必需。
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2
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本文引用的文献

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Nat Cell Biol. 2011 Jun;13(6):708-14. doi: 10.1038/ncb2242. Epub 2011 May 15.
2
Aurora kinases and spindle assembly: variations on a common theme?极光激酶与纺锤体装配:万变不离其宗?
Cell Cycle. 2011 Mar 15;10(6):895-903. doi: 10.4161/cc.10.6.14909.
3
Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.
Biochem Res Int. 2012;2012:195903. doi: 10.1155/2012/195903. Epub 2012 Jul 19.
中心体蛋白 192kDa(Cep192)通过参与细胞器特异性极光激酶 A 的激活来促进中心体驱动的纺锤体组装。
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21022-7. doi: 10.1073/pnas.1014664107. Epub 2010 Nov 19.
4
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.在胚胎发育过程中,黏着斑激酶(FAK)的激酶非依赖性和依赖性功能在血管内皮细胞存活和屏障功能中的作用。
J Cell Biol. 2010 Jun 14;189(6):955-65. doi: 10.1083/jcb.200912094. Epub 2010 Jun 7.
5
The elegans of spindle assembly.纺锤体组装的线虫。
Cell Mol Life Sci. 2010 Jul;67(13):2195-213. doi: 10.1007/s00018-010-0324-8. Epub 2010 Mar 26.
6
Aurora kinase inhibitors--rising stars in cancer therapeutics?极光激酶抑制剂——癌症治疗领域的后起之秀?
Mol Cancer Ther. 2010 Feb;9(2):268-78. doi: 10.1158/1535-7163.MCT-09-0765. Epub 2010 Feb 2.
7
Mechanisms of mitotic spindle assembly and function.有丝分裂纺锤体组装与功能的机制。
Int Rev Cytol. 2008;265:111-58. doi: 10.1016/S0074-7696(07)65003-7.
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Asymmetric cell division and axis formation in the embryo.胚胎中的不对称细胞分裂与轴形成。
WormBook. 2005 Oct 15:1-20. doi: 10.1895/wormbook.1.30.1.
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Centrosomes promote timely mitotic entry in C. elegans embryos.中心体促进秀丽隐杆线虫胚胎有丝分裂的及时启动。
Dev Cell. 2007 Apr;12(4):531-41. doi: 10.1016/j.devcel.2007.02.015.
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