Reboutier David, Benaud Christelle, Prigent Claude
Unité Mixte de Recherche 6290, Équipe labellisée Ligue, Centre National de la Recherche Scientifique, Rennes, France; Institut de Génétique et Développement de Rennes, Université Rennes 1, Rennes, France.
Front Oncol. 2015 Dec 21;5:290. doi: 10.3389/fonc.2015.00290. eCollection 2015.
Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog-specific version of Aurora A and small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms.
直到最近，人们对极光激酶A在有丝分裂过程中的功能的了解还仅限于前中期事件，特别是中心体成熟、G2/M期转换和有丝分裂纺锤体组装。然而，也有人怀疑极光激酶A参与了中期后事件，但由于进行适当实验存在技术困难，这一点尚未得到明确证实。极光激酶A的类似物特异性版本和小分子抑制剂的最新进展首次证明，胞质分裂早期步骤需要极光激酶A。与前中期一样极光激酶A在后期发挥多种功能，主要参与星状微管动力学以及中央纺锤体的组装和功能。本综述描述了用于解读极光激酶A在有丝分裂后期新功能的实验系统，并将这些功能置于胞质分裂机制的背景下。
