水和其他极性质子溶剂对杂环异构化的显著促进作用：中氮茚的无金属合成。
Remarkable facilitation of hetero-cycloisomerizations with water and other polar protic solvents: metal-free synthesis of indolizines.
作者信息
Hardin Narayan Alison R, Sarpong Richmond
机构信息
Department of Chemistry, University of California, Berkeley, California, 94720, USA.
出版信息
Green Chem. 2010;12(9):1556-1559. doi: 10.1039/C0GC00198H.
Abstract
Hetero-cycloisomerization reactions of propargylic alcohol derivatives leading to indolizines have been demonstrated to proceed in the presence of water alone. This stands as a significant advance over the previous methods using Pt, Cu or Ag salts paired with ligands in organic solvents such as benzene, acetonitrile or methylene chloride.
摘要
已证明，炔丙醇衍生物生成中氮茚的杂环异构化反应仅在水存在的情况下就能进行。与之前在苯、乙腈或二氯甲烷等有机溶剂中使用铂、铜或银盐与配体配合的方法相比，这是一个重大进展。
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