黎豆属植物叶乙醇提取物的抗惊厥和抗癫痫作用：在白化大鼠癫痫中多巴胺能系统作用的研究。
Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats.
机构信息
Department of Pharmacology, University Department of Pharmaceutical Sciences, Bhubaneswar-751 004, Orissa, India.
出版信息
Indian J Pharmacol. 2011 Apr;43(2):197-9. doi: 10.4103/0253-7613.77368.
Abstract
OBJECTIVE
To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats.
MATERIALS AND METHODS
Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed.
RESULTS
M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE.
CONCLUSIONS
M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.
摘要
目的
评估黎豆叶子在白化大鼠中的抗僵住和抗癫痫活性。
材料和方法
采用氟哌啶醇诱导的僵住（HIC）、最大电休克（MES）法、毛果芸香碱诱导的癫痫持续状态（PISE）和黎豆的单次剂量效应进行研究。
结果
黎豆（100mg/kg）在 HIC、MES 和 PISE 中具有显著的抗僵住和抗癫痫活性。
结论
黎豆提取物具有成为抗僵住和抗癫痫药物的潜力。多巴胺和 5-HT 可能在这种活性中发挥作用。
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