Mycobacteriology Research Center Virology Research Center, NRITLD, Masih-Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ann Thorac Med. 2011 Apr;6(2):91-5. doi: 10.4103/1817-1737.78429.
In preparation for pandemic HINI or H1N1 influenza (H1N1) it is necessary to identify factors associated with mortality of patients with HINI and hospital admissions to intensive care unit (ICU) of patients diagnosed in 2009 with HINI.
To describe the clinical and epidemiological features associated with 2009 HIN1 mortality and ICU patient admissions to Masih Daneshvari Teaching Hospital, Iran.
A retrospective cross-sectional study was conducted among patients with mortality and admissions to ICU with confirmed HINI. Demographic, clinical, laboratory, radiological findings, and epidemiologic data were abstracted from medical records, using a standardized datasheet.
From June through December 2009, 20 out of the 46 confirmed hospitalized patients with confirmed H1NI were admitted to the ICU and 7 (15%) died. Among various variables, opium inhalation (P = 0.01), having productive cough, hemoptysis, chest pain, confusion, and loss of consciousness were significantly related to ICU admission (P < 0.05). Pleural effusion (P = 0.006), elevated liver enzymes, as well as CPK and LDH level were significantly relevant to ICU admission (P < 0.05). Delayed antiviral treatment was more common among patients who died and the elderly.
Patients who were admitted to ICU with confirmed H1N1 included the following risk factors: delayed initiation of antiviral therapy, history of opium inhalation and symptoms including; productive cough, hemoptysis, chest pain, confusion, and loss of consciousness. The mortality rate in the study population was high but compares favorably with other recent published studies.
为应对大流行的 H1N1 或 H1N1 流感，有必要确定与 2009 年确诊的 H1N1 患者的死亡率和入住重症监护病房（ICU）相关的因素。
描述与 2009 年 H1N1 死亡率和入住 ICU 的患者相关的临床和流行病学特征，这些患者在伊朗的 Masih Daneshvari 教学医院接受治疗。
采用回顾性病例对照研究，对死亡率和入住 ICU 的确诊为 H1N1 的患者进行研究。从病历中提取人口统计学、临床、实验室、影像学和流行病学数据，使用标准化数据表。
2009 年 6 月至 12 月，46 例确诊的住院 H1N1 患者中有 20 例入住 ICU，其中 7 例（15%）死亡。在各种变量中，阿片类药物吸入（P=0.01）、有咳痰、咯血、胸痛、意识混乱和意识丧失与入住 ICU 显著相关（P<0.05）。胸腔积液（P=0.006）、肝酶升高以及 CPK 和 LDH 水平与入住 ICU 显著相关（P<0.05）。抗病毒治疗延迟在死亡和老年患者中更为常见。
入住 ICU 的确诊为 H1N1 的患者存在以下危险因素：抗病毒治疗延迟、阿片类药物吸入史和包括咳痰、咯血、胸痛、意识混乱和意识丧失在内的症状。研究人群的死亡率较高，但与其他最近发表的研究相比，情况较好。
