Zhang Dongliang, Lijuan Gu, Jingjie Li, Zheng Li, Wang Chunyan, Wang Zhen, Liu Lei, Mira Li, Sung Changkeun
from Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Korea.
Indian J Dermatol. 2011 Jan;56(1):14-8. doi: 10.4103/0019-5154.77544.
Hair loss is seen as an irreversible process. Most research concentrates on how to elongate the anagen, reduce the negative factors of obstructing hair growth and improve the hair number and size.
In our experiment, we tried to prove that the cow placenta extract can promote hair growth by elongating hair shaft and increasing hair follicle number.
Cow placenta extract (CPE), water and minoxidil applied separately on the back of depilated B57CL/6 mice for the case, negative and positive control respectively. We checked the proliferation of cells which are resident in hair sheath, and the expression of a few growth factors which stimulate hair growth.
Result shows that placenta extract more efficiently accelerates cell division and growth factor expression, by raising the insulin-like growth factor (IGF-1) mRNA and protein level to increase HF size and hair length.
The extract is not a purified product; so, it is less effective than minoxidil, which is approved by the US FDA for the treatment of male pattern baldness. If refinement is done, the placenta extract would be a good candidate medicine for hair loss.
脱发被视为一个不可逆的过程。大多数研究集中在如何延长生长期、减少阻碍头发生长的负面因素以及增加头发数量和粗细。
在我们的实验中，我们试图证明牛胎盘提取物可以通过延长毛干和增加毛囊数量来促进头发生长。
将牛胎盘提取物（CPE）、水和米诺地尔分别涂抹在脱毛的B57CL/6小鼠背部，分别作为实验组、阴性对照组和阳性对照组。我们检测了毛鞘中驻留细胞的增殖情况以及一些刺激头发生长的生长因子的表达。
结果表明，胎盘提取物通过提高胰岛素样生长因子（IGF-1）的mRNA和蛋白质水平，更有效地加速细胞分裂和生长因子表达，以增加毛囊大小和头发长度。
该提取物不是一种纯化产品；因此，它的效果不如美国食品药品监督管理局（FDA）批准用于治疗男性型秃发的米诺地尔。如果进行提纯，胎盘提取物将是治疗脱发的一种良好候选药物。
