Tumwikirize W A, Ogwal-Okeng J W, Vernby A, Anokbonggo W W, Gustafsson L L, Lundborg S C
Department of Pharmacology & Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda.
Afr Health Sci. 2011 Mar;11(1):72-8.
The burden of both community and hospital acquired adverse drug reactions (ADRs) are some of the important issues in pharmacotherapy. At the time of this study there was very scanty literature in this area from Africa.
This study was done to determine the frequency and characteristics of ADRs in patients admitted on medical wards in public hospitals.
This was a longitudinal observational study on 728 adult patients on medical wards in one regional and one district hospitals. Community and hospital acquired ADRs were assessed.
Thirty three patients (4.5%) were admitted with suspected ADR, and an ADR was the reason for hospitalization in 1.5%. Most ADRs were due to antiparasitic products, mainly quinine (61%). Community acquired ADRs prolonged hospital stay, 5.6 days vs 4.0 days (p-value < 0.001). During hospitalization ADRs occurred in 49.5% of the patients. Antiparasitic products, predominantly quinine, were the commonest drugs class associated with ADRs (85.9%). Hospital acquired ADRs did not affect hospital stay, 4.2 days vs 3.9 (p-value 0.129).
ADRs are an important cause of morbidity in patients, both in the community and in hospitals, and the majority are associated with the commonly used drugs.
社区获得性和医院获得性药物不良反应（ADR）的负担是药物治疗中的一些重要问题。在本研究开展之时，非洲该领域的文献非常匮乏。
本研究旨在确定公立医院内科病房住院患者药物不良反应的发生率及特征。
这是一项针对一家地区医院和一家区级医院内科病房728例成年患者的纵向观察性研究。对社区获得性和医院获得性药物不良反应进行评估。
33例患者（4.5%）因疑似药物不良反应入院，1.5%的患者因药物不良反应而住院。大多数药物不良反应由抗寄生虫产品引起，主要是奎宁（61%）。社区获得性药物不良反应延长了住院时间，分别为5.6天和4.0天（p值<0.001）。住院期间，49.5%的患者发生了药物不良反应。抗寄生虫产品，主要是奎宁，是与药物不良反应相关的最常见药物类别（85.9%）。医院获得性药物不良反应未影响住院时间，分别为4.2天和3.9天（p值0.129）。
药物不良反应是社区和医院患者发病的重要原因，大多数与常用药物有关。
