Verdun di Cantogno Elisabetta, Russell Susan, Snow Tom
Global Clinical Development Unit, Merck Serono S.A. - Geneva, Switzerland;
Patient Prefer Adherence. 2011 Mar 28;5:173-80. doi: 10.2147/PPA.S14903.
All established disease-modifying drugs for multiple sclerosis require parenteral administration, which can cause difficulties for some patients, sometimes leading to suboptimal adherence. A new electronic autoinjection device has been designed to address these issues.
Patients with relapsing multiple sclerosis currently receiving subcutaneous or intramuscular interferon beta-1a, interferon beta-1b, or glatiramer acetate completed an online questionnaire (July 4-25, 2008) that surveyed current injection practices, experiences with current injection methods, and impressions and appeal of the new device.
In total, 422 patients completed the survey, of whom 44% used autoinjectors, 43% prefilled syringes, and 13% syringes and vials; overall, 66% currently self-injected. Physical and psychological barriers to self-injection included difficulty with injections, needle phobia, and concerns over correct injection technique. Only 40% of respondents were "very satisfied" with their current injection method. The new electronic autoinjector was rated as "very appealing" by 65% of patients. The benefits of the new device included the ability to customize injection settings and to review dosing history.
New technologies may help patients overcome physical and psychological barriers to self-injection. The combination of a reliable and flexible autoinjection device with dose-monitoring technology may improve communication between health care professionals and patients, and improve treatment adherence.
所有已确立的用于治疗多发性硬化症的疾病修正药物都需要肠胃外给药，这可能给一些患者带来困难，有时会导致依从性欠佳。一种新型电子自动注射装置已被设计出来以解决这些问题。
目前正在接受皮下或肌肉注射β-1a干扰素、β-1b干扰素或醋酸格拉替雷的复发型多发性硬化症患者完成了一份在线调查问卷（2008年7月4日至25日），该问卷调查了当前的注射做法、对当前注射方法的体验以及对新装置的印象和吸引力。
共有422名患者完成了调查，其中44%使用自动注射器，43%使用预填充注射器，13%使用注射器和药瓶；总体而言，66%的患者目前自行注射。自行注射的身体和心理障碍包括注射困难、针头恐惧症以及对正确注射技术的担忧。只有40%的受访者对他们当前的注射方法“非常满意”。65%的患者认为新型电子自动注射器“非常有吸引力”。新装置的优点包括能够定制注射设置并查看给药历史记录。
新技术可能有助于患者克服自行注射的身体和心理障碍。可靠且灵活的自动注射装置与剂量监测技术相结合，可能会改善医护人员与患者之间的沟通，并提高治疗依从性。
