Yonemura Y, Kaji M, Takamura H, Sugiyama K, Ninomiya I, Tsugawa K, Fujimura T, Fujita H, Yamaguchi A, Nishimura G, Miyazaki I
Int J Oncol. 1993 Apr;2(4):577-82. doi: 10.3892/ijo.2.4.577.
The prognostic value of nucleolar organizer region (Ag-NOR) and ploidy status in 233 gastric cancer was determined. In addition, correlation of bromodeoxyuridine labeling indices (BrdU LIs) and Ag-NOR scores was studied. The proportion of Ag-NOR scores varied from 1.85 to 12.0 (mean, 3.6; S.D., 1.9). A significant correlation was found between Ag-NOR scores and BrdU LIs, tumor size, serosal invasion, and lymph node metastasis. By univariate analysis, Ag-NOR score was proved to be a significant prognostic indicator. However, Cox regression analysis revealed that Ag-NOR scores and DNA ploidy were not independent prognostic parameters. However, when the combination analysis of Ag-NOR scores and DNA ploidy was entered into the Cox model, this parameter emerged as an independent prognostic parameter. These studies indicate that Ag-NOR scores reflect proliferative activity of gastric cancer, and that the Ag-NOR scores may possibly be useful prognostic parameters, when combined with DNA ploidy.
研究了233例胃癌中核仁组成区（Ag-NOR）和倍体状态的预后价值。此外，还研究了溴脱氧尿苷标记指数（BrdU LIs）与Ag-NOR评分的相关性。Ag-NOR评分比例在1.85至12.0之间（平均值为3.6；标准差为1.9）。发现Ag-NOR评分与BrdU LIs、肿瘤大小、浆膜侵犯及淋巴结转移之间存在显著相关性。单因素分析表明，Ag-NOR评分是一个显著的预后指标。然而，Cox回归分析显示，Ag-NOR评分和DNA倍体不是独立的预后参数。但是，当将Ag-NOR评分与DNA倍体的联合分析纳入Cox模型时，该参数成为一个独立的预后参数。这些研究表明，Ag-NOR评分反映了胃癌的增殖活性，并且当与DNA倍体结合时，Ag-NOR评分可能是有用的预后参数。
