Diabetic Cardiovascular Disease Center, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Ave. Campus, PO Box 8086, St Louis, MO 63110-1093, USA.
Cardiovasc Drugs Ther. 2011 Apr;25(2):151-9. doi: 10.1007/s10557-011-6290-z.
Research into small non-coding RNAs (ncRNA) has fundamentally transformed our understanding of gene regulatory networks, especially at the post-transcriptional level. Although much is now known about the basic biology of small ncRNAs, our ability to recognize the impact of small ncRNA in disease states is preliminary, and the ability to effectively target them in vivo is very limited. However, given the larger and growing focus on targeting RNAs for disease therapeutics, what we do know about the intrinsic biology of these small RNAs makes them potentially attractive targets for pharmacologic manipulation. With that in mind, this review provides an introduction to the biology of small ncRNA, using microRNA (miRNA) and small nucleolar RNA (snoRNA) as examples.
对小非编码 RNA（ncRNA）的研究从根本上改变了我们对基因调控网络的理解，尤其是在后转录水平。尽管我们现在已经了解了小 ncRNA 的基本生物学特性，但我们识别小 ncRNA 在疾病状态下的影响的能力还处于初步阶段，并且在体内有效靶向它们的能力非常有限。然而，鉴于人们越来越关注针对 RNA 的疾病治疗药物，我们对这些小 RNA 的内在生物学特性的了解使它们成为药物干预的潜在有吸引力的靶点。有鉴于此，本综述以 microRNA（miRNA）和 small nucleolar RNA（snoRNA）为例，介绍了小 ncRNA 的生物学特性。
