神经系统中的非编码RNA
Non-coding RNAs in the nervous system.
作者信息
Mehler Mark F, Mattick John S
机构信息
ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia.
出版信息
J Physiol. 2006 Sep 1;575(Pt 2):333-41. doi: 10.1113/jphysiol.2006.113191. Epub 2006 Jun 29.
Abstract
Increasing evidence suggests that the development and function of the nervous system is heavily dependent on RNA editing and the intricate spatiotemporal expression of a wide repertoire of non-coding RNAs, including micro RNAs, small nucleolar RNAs and longer non-coding RNAs. Non-coding RNAs may provide the key to understanding the multi-tiered links between neural development, nervous system function, and neurological diseases.
摘要
越来越多的证据表明，神经系统的发育和功能严重依赖于RNA编辑以及多种非编码RNA（包括微小RNA、小核仁RNA和较长的非编码RNA）复杂的时空表达。非编码RNA可能是理解神经发育、神经系统功能和神经疾病之间多层次联系的关键。
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