细胞结构中的磷酸肌醇。
Phosphoinositides in cell architecture.
机构信息
Department of Anatomy, University of California, San Francisco, San Francisco, California 94143-2140, USA.
出版信息
Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a004796. doi: 10.1101/cshperspect.a004796.
Abstract
Inositol phospholipids have been implicated in almost all aspects of cellular physiology including spatiotemporal regulation of cellular signaling, acquisition of cellular polarity, specification of membrane identity, cytoskeletal dynamics, and regulation of cellular adhesion, motility, and cytokinesis. In this review, we examine the critical role phosphoinositides play in these processes to execute the establishment and maintenance of cellular architecture. Epithelial tissues perform essential barrier and transport functions in almost all major organs. Key to their development and function is the establishment of epithelial cell polarity. We place a special emphasis on highlighting recent studies demonstrating phosphoinositide regulation of epithelial cell polarity and how individual cells use phosphoinositides to further organize into epithelial tissues.
摘要
肌醇磷脂几乎参与了细胞生理学的各个方面，包括细胞信号的时空调节、细胞极性的获得、膜特性的特化、细胞骨架动力学以及细胞黏附、运动和胞质分裂的调节。在这篇综述中，我们研究了磷酸肌醇在这些过程中发挥的关键作用，以执行细胞结构的建立和维持。上皮组织在几乎所有主要器官中都发挥着重要的屏障和运输功能。其发育和功能的关键是上皮细胞极性的建立。我们特别强调突出最近的研究表明，磷酸肌醇调节上皮细胞极性，以及单个细胞如何利用磷酸肌醇进一步组织成上皮组织。
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Dev Cell. 2010 Sep 14;19(3):377-88. doi: 10.1016/j.devcel.2010.08.011.
2
Sequential activation of apical and basolateral contractility drives ascidian endoderm invagination.顶端和基底侧收缩力的顺序激活驱动着内胚层内卷。
Curr Biol. 2010 Sep 14;20(17):1499-510. doi: 10.1016/j.cub.2010.06.075. Epub 2010 Aug 5.
3
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4
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