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本文引用的文献

1
Complete genome sequence of Enterobacter cloacae subsp. cloacae type strain ATCC 13047.阴沟肠杆菌亚种阴沟肠杆菌模式株 ATCC 13047 的全基因组序列。
J Bacteriol. 2010 May;192(9):2463-4. doi: 10.1128/JB.00067-10. Epub 2010 Mar 5.
2
Functional gene cloning and characterization of the SsmE multidrug efflux pump from Serratia marcescens.粘质沙雷氏菌SsmE多药外排泵的功能基因克隆与特性分析
Biol Pharm Bull. 2008 Mar;31(3):516-9. doi: 10.1248/bpb.31.516.
3
Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.阴沟肠杆菌AcrAB-TolC外排泵的克隆、核苷酸测序与分析及其在临床分离株中对抗生素耐药性的作用测定
Antimicrob Agents Chemother. 2007 Sep;51(9):3247-53. doi: 10.1128/AAC.00072-07. Epub 2007 Jul 16.
4
RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae.转录调节因子RamA和RND型外排泵AcrAB与阴沟肠杆菌对替加环素的敏感性降低有关。
Microb Drug Resist. 2007 Spring;13(1):1-6. doi: 10.1089/mdr.2006.9990.
5
Resistance in gram-negative bacteria: enterobacteriaceae.革兰氏阴性菌中的耐药性：肠杆菌科细菌
Am J Med. 2006 Jun;119(6 Suppl 1):S20-8; discussion S62-70. doi: 10.1016/j.amjmed.2006.03.013.
6
Clonal occurrences of multidrug-resistant Gram-negative bacilli: report from the Meropenem Yearly Susceptibility Test Information Collection Surveillance Program in the United States (2004).多重耐药革兰氏阴性杆菌的克隆出现情况：来自美国美罗培南年度药敏试验信息收集监测项目的报告（2004年）
Diagn Microbiol Infect Dis. 2006 Apr;54(4):249-57. doi: 10.1016/j.diagmicrobio.2005.10.010. Epub 2006 Feb 8.
7
Extensive hospital-wide spread of a multidrug-resistant enterobacter cloacae clone, with late detection due to a variable antibiogram and frequent patient transfer.一种耐多药阴沟肠杆菌克隆在医院内广泛传播，由于抗菌谱多变且患者频繁转运导致检测延迟。
J Clin Microbiol. 2006 Feb;44(2):518-24. doi: 10.1128/JCM.44.2.518-524.2006.
8
Quantitative real-time PCR for detection and identification of Candidatus Liberibacter species associated with citrus huanglongbing.用于检测和鉴定与柑橘黄龙病相关的“Candidatus Liberibacter”菌属的定量实时聚合酶链反应。
J Microbiol Methods. 2006 Jul;66(1):104-15. doi: 10.1016/j.mimet.2005.10.018. Epub 2006 Jan 18.
9
Plasmid-mediated high-level gentamicin resistance among enteric bacteria isolated from pet turtles in Louisiana.从路易斯安那州宠物龟分离出的肠道细菌中质粒介导的高水平庆大霉素耐药性
Appl Environ Microbiol. 2006 Jan;72(1):306-12. doi: 10.1128/AEM.72.1.306-312.2006.
10
High prevalence of the plasmid-mediated quinolone resistance determinant qnrA in multidrug-resistant Enterobacteriaceae from blood cultures in Liverpool, UK.英国利物浦血培养中多重耐药肠杆菌科细菌中质粒介导的喹诺酮耐药决定子qnrA的高流行率
J Antimicrob Chemother. 2005 Dec;56(6):1115-7. doi: 10.1093/jac/dki388. Epub 2005 Oct 31.

SugE，SMR 家族转运蛋白的新成员，有助于阴沟肠杆菌的抗菌药物耐药性。

SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae.

机构信息

Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.

出版信息

Antimicrob Agents Chemother. 2011 Aug;55(8):3954-7. doi: 10.1128/AAC.00094-11. Epub 2011 May 16.

DOI:10.1128/AAC.00094-11
PMID:21576447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3147620/
Abstract

We cloned a gene, sugE, from the chromosome of Enterobacter cloacae ATCC 13047. Analysis of the susceptibilities of the sugE-containing strain (Escherichia coli KAM32/pSUGE28) and sugE-deficient E. cloacae (EcΔsugE) showed that SugE confers resistance to cetyltrimethylammonium bromide, cetylpyridinium chloride, tetraphenylphosphonium, benzalkonium chloride, ethidium bromide, and sodium dodecyl sulfate. We also investigated expression of sugE. We confirm here that SugE from E. cloacae is an SMR family transporter as determined by observing its energy-dependent drug efflux activity.

摘要

我们从肠杆菌 cloacae ATCC 13047 的染色体中克隆了一个 sugE 基因。对含 sugE 菌株（大肠杆菌 KAM32/pSUGE28）和 sugE 缺陷型肠杆菌 cloacae（EcΔsugE）的药敏分析表明，SugE 赋予了它们对十六烷基三甲基溴化铵、十六烷基氯化吡啶、四苯膦、苯扎氯铵、溴化乙锭和十二烷基硫酸钠的抗性。我们还研究了 sugE 的表达情况。我们在这里证实，来自肠杆菌 cloacae 的 SugE 是一种 SMR 家族转运蛋白，这是通过观察其能量依赖性药物外排活性来确定的。