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从不同病理患者中分离得到的两株弯曲杆菌的毒力基因型和表型。

Virulence genotype and phenotype of two clinical isolates of Arcobacter butzleri obtained from patients with different pathologies.

机构信息

MikroIker Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006, Vitoria-d Gasteiz, Spain.

Bioaraba, Microbiology, Infectious Diseases, Antimicrobial Agents and Gene Therapy, 01006, Vitoria-Gasteiz, Spain.

出版信息

Arch Microbiol. 2023 Nov 4;205(12):369. doi: 10.1007/s00203-023-03709-3.

DOI:10.1007/s00203-023-03709-3
PMID:37923944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10624747/
Abstract

The surge in human arcobacteriosis has increased interest in determining the mechanisms involved in the pathogenesis of Arcobacter butzleri. Here, genomic analyses and in vitro Caco-2 infection, motility, urease and antimicrobial susceptibility testing (AST) assays were used to characterise the virulence and antimicrobial resistance (AMR) determinants of strains HC-1, isolated from a patient with travellers' diarrhoea, and HC-2, isolated from another with pruritus. AMR determinants conferring resistance to tetracycline (tetO, present in both genomes) and to ampicillin and amoxicillin-clavulanic acid (bla3, present in HC-2) were identified. The same determinants associated with flagellum, chemotaxis, adhesion and invasion were detected in both, but HC-1 lacked eight flagellar genes. The urease cluster was only present in HC-1. Motility and urease tests confirmed the genetic differences between strains, but no genetic marker related to the inability of HC-2 to adhere and invade was identified. This inability could be conditioning the patient's pathology.

摘要

人类弯曲菌病的激增增加了人们对确定弯曲杆菌发病机制中涉及的机制的兴趣。在这里，使用基因组分析和体外 Caco-2 感染、运动性、脲酶和抗菌药物敏感性测试 (AST) 测定来表征从旅行者腹泻患者中分离出的菌株 HC-1 和从另一位瘙痒患者中分离出的菌株 HC-2 的毒力和抗菌药物耐药性 (AMR) 决定因素。鉴定出对四环素（两种基因组中均存在的 tetO）以及氨苄西林和阿莫西林克拉维酸（bla3，存在于 HC-2 中）具有耐药性的 AMR 决定因素。在这两种菌株中都检测到与鞭毛、趋化性、粘附和侵袭相关的相同决定因素，但 HC-1 缺少 8 个鞭毛基因。脲酶簇仅存在于 HC-1 中。运动性和脲酶试验证实了菌株之间的遗传差异，但未鉴定出与 HC-2 无法粘附和侵袭相关的遗传标记。这种无能可能影响了患者的病理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/3453f2f8359b/203_2023_3709_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/e003fac69ec0/203_2023_3709_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/9186d387f6c3/203_2023_3709_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/3453f2f8359b/203_2023_3709_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/e003fac69ec0/203_2023_3709_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/9186d387f6c3/203_2023_3709_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f5d/10624747/3453f2f8359b/203_2023_3709_Fig3_HTML.jpg

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