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3-[N-(叔丁氧羰基)甲基氨基]-4-甲氧基亚氨基-3-甲基哌啶-1-羧酸叔丁酯

tert-Butyl 3-[N-(tert-butoxy-carbonyl)methyl-amino]-4-methoxy-imino-3-methyl-piperidine-1-carboxyl-ate.

作者信息

Wan Zhilong, Chai Yun, Liu Mingliang, Guo Huiyuan

机构信息

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 8;65(Pt 2):o256. doi: 10.1107/S1600536808044255.

DOI:10.1107/S1600536808044255
PMID:21581872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968324/
Abstract

The title compound, C(18)H(33)N(3)O(5), was prepared from N-tert-butoxy-carbonyl-4-piperidone using a nine-step reaction, including condensation, methyl-ation, oximation, hydrolysis, esterification, ammonolysis, Hoffmann degradation, tert-butoxy-carbonyl protection and methyl-ation. The E configuration of the methyl-oxime geometry of the compound is confirmed.

摘要

标题化合物C(18)H(33)N(3)O(5)由N-叔丁氧羰基-4-哌啶酮经九步反应制备而成，包括缩合、甲基化、肟化、水解、酯化、氨解、霍夫曼降解、叔丁氧羰基保护和甲基化。该化合物甲基肟几何构型的E构型得到确证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d33/2968324/2d6e0048ad63/e-65-0o256-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d33/2968324/2d6e0048ad63/e-65-0o256-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d33/2968324/2d6e0048ad63/e-65-0o256-fig1.jpg

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Therapeutic advances of new fluoroquinolones.新型氟喹诺酮类药物的治疗进展
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