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(7R,8S,8aS)-8-Hydr-oxy-7-phenyl-perhydro-indolizin-3-one.

作者信息

Svorc Lubomír, Vrábel Viktor, Marchalín Stefan, Safář Peter, Kožíšek Jozef

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 May 23;65(Pt 6):o1368-9. doi: 10.1107/S1600536809018455.

DOI:10.1107/S1600536809018455
PMID:21583218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2969627/
Abstract

In the title compound, C(14)H(17)NO(2), the six-membered ring of the indolizine system adopts a chair conformation. In the crystal, mol-ecules form chains parallel to the b axis via inter-molecular O-H⋯O hydrogen bonds. The absolute mol-ecular configuration was assigned from the synthesis.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1196/2969627/5db4d4eb5c96/e-65-o1368-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1196/2969627/e61b1c25798d/e-65-o1368-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1196/2969627/5db4d4eb5c96/e-65-o1368-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1196/2969627/e61b1c25798d/e-65-o1368-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1196/2969627/5db4d4eb5c96/e-65-o1368-fig2.jpg

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本文引用的文献

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Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 28;65(Pt 4):o895-6. doi: 10.1107/S160053680901085X.
2
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.哺乳动物分泌型磷脂酶A2的高特异性和广泛有效的抑制剂。
J Med Chem. 2008 Aug 14;51(15):4708-14. doi: 10.1021/jm800422v. Epub 2008 Jul 8.
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A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
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Regiodivergent metal-catalyzed rearrangement of 3-iminocyclopropenes into N-fused heterocycles.3-亚氨基环丙烯的区域发散性金属催化重排反应生成氮稠合杂环化合物。
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Gold-catalyzed multicomponent synthesis of aminoindolizines from aldehydes, amines, and alkynes under solvent-free conditions or in water.在无溶剂条件下或在水中，通过金催化由醛、胺和炔烃进行多组分合成氨基中氮茚。
Org Lett. 2007 Oct 11;9(21):4323-6. doi: 10.1021/ol701886e. Epub 2007 Sep 14.
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Pt-catalyzed cyclization/1,2-migration for the synthesis of indolizines, pyrrolones, and indolizinones.铂催化环化/1,2-迁移用于合成中氮茚、吡咯烷酮和中氮茚酮。
Org Lett. 2007 Mar 15;9(6):1169-71. doi: 10.1021/ol0701971. Epub 2007 Feb 20.
7
General and direct synthesis of 3-aminoindolizines and their analogues via Pd/Cu-catalyzed sequential cross-coupling/cycloisomerization reactions.通过钯/铜催化的顺序交叉偶联/环异构化反应实现3-氨基中氮茚及其类似物的通用直接合成。
Org Lett. 2007 Feb 1;9(3):409-12. doi: 10.1021/ol062766v.
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A quantitative structure-activity relationship study on a novel class of calcium-entry blockers: 1-[(4-(aminoalkoxy)phenyl)sulphonyl]indolizines.
Eur J Med Chem. 2003 Oct;38(10):867-73. doi: 10.1016/j.ejmech.2003.08.001.
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