J.K. TRIVEDI, M.D., Associate Professor, Department of Psychiatry, K.G's Medical College, Lucknow.
Indian J Psychiatry. 1997 Jan;39(1):41-8.
Many studies have reported involvement of monoamine neurotransmission in suicide through measurement of serotonin and its main metabolite, 5-HIAA, in brain of suicide victims and in CSF of suicide attempters. 23 non-depressed non-psychotic suicide attempters and equal number of controls were selected, and all the subjects were screened on Cornell Medical Index. Suicide attempters were assessed on Risk-Rescue Rating Scale and were divided into non-violent suicide attempters (N= 12) and violent suicide attempters (N= II). CSF of all subjects was collected by lumbar puncture and CSF 5-HIAA was measured by high performance liquid chromatography with electro-chemical detector. Risk-rescue rating score was significantly higher in violent suicide attempters as compared to non-violent suicide attempters. Mean CSF- 5- HIAA was significantly lower in suicide attempters as compared to normal controls. Mean CSF 5-HIAA was significantly lower in violent suicide attempters as compared to non-violent suicide attempters.
许多研究通过测量自杀受害者大脑中的血清素及其主要代谢物 5-羟吲哚乙酸（5-HIAA）以及自杀未遂者的脑脊液中的这些物质，报告了单胺神经递质在自杀中的作用。选择了 23 名非抑郁非精神病的自杀未遂者和数量相等的对照组，所有的受试者都接受了康奈尔医学指数的筛查。自杀未遂者通过风险救助评分量表进行评估，并分为非暴力自杀未遂者（N=12）和暴力自杀未遂者（N=11）。通过腰椎穿刺收集所有受试者的脑脊液，并通过高效液相色谱法与电化学检测器测量脑脊液 5-HIAA。与非暴力自杀未遂者相比，暴力自杀未遂者的风险救助评分显著更高。与正常对照组相比，自杀未遂者的脑脊液 5-HIAA 平均值明显较低。与非暴力自杀未遂者相比，暴力自杀未遂者的脑脊液 5-HIAA 平均值明显较低。
