Bioulac B, Benezech M, Renaud B, Noel B, Roche D
Biol Psychiatry. 1980 Dec;15(6):917-23.
In six XYY patients suffering from aggressiveness and admitted by order of law into a security setting for acts of violence, the estimation of cerebrospinal fluid amine metabolites before and after a probenecid test revealed a clear decrease in the turnover of central serotonin (5-HT) while that of dopamine (DA) was unchanged. The treatment with the 5-HT precursor, L-5-hydroxytryptophan (L-5-HTP), in five of the XYYs resulted in a clinical status equivalent to that observed when the patients were previously treated by conventional neuroleptics.
在6名患有攻击性且因暴力行为依法被收治于安全机构的XYY患者中，对丙磺舒试验前后脑脊液胺类代谢产物的评估显示，中枢5-羟色胺（5-HT）的周转率明显下降，而多巴胺（DA）的周转率未变。在5名XYY患者中使用5-HT前体L-5-羟色氨酸（L-5-HTP）进行治疗，其临床状况与患者先前接受传统抗精神病药物治疗时观察到的情况相当。
