Bollini P, Andreani A, Colombo F, Bellantuono C, Beretta P, Arduini A, Galli T, Tognoni G
Br J Psychiatry. 1984 Jan;144:25-7. doi: 10.1192/bjp.144.1.25.
The strategy of high-dose intramuscular haloperidol as routinely applied in a general hospital psychiatric ward to 74 successive patients, 33 of whom stayed only up to seven days, and a further 34 up to 15 days, led to a complete recovery in only six, and complete lack of change in 23. Adverse reactions were recorded in 42, severe enough to stop treatment in eight; there were three deaths. In view of this risk-benefit analysis, systematic application of this high dose strategy to get a more rapid turnover of patients is unjustified.
在一家综合医院精神科病房，对74例连续患者常规应用大剂量肌肉注射氟哌啶醇的策略，其中33例仅住院7天，另外34例住院15天。结果仅有6例完全康复，23例毫无变化。42例出现不良反应，严重到足以导致8例停止治疗；有3例死亡。鉴于这种风险效益分析，为了更快地周转患者而系统应用这种高剂量策略是不合理的。
