Serviço de Oncologia Clínica, Hospital do Câncer II, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
Rev Saude Publica. 2011 Aug;45(4):661-7. doi: 10.1590/s0034-89102011005000029. Epub 2011 May 13.
To assess overall survival of women with cervical cancer and describe prognostic factors associated.
A total of 3,341 cases of invasive cervical cancer diagnosed at the Brazilian Cancer Institute, Rio de Janeiro, southeastern Brazil, between 1999 and 2004 were selected. Clinical and pathological characteristics and follow-up data were collected. There were performed a survival analysis using Kaplan-Meier curves and a multivariate analysis through Cox model.
Of all cases analyzed, 68.3% had locally advanced disease at the time of diagnosis. The 5-year overall survival was 48%. After multivariate analysis, tumor staging at diagnosis was the single variable significantly associated with prognosis (p<0.001). There was seen a dose-response relationship between mortality and clinical staging, ranging from 27.8 to 749.6 per 1,000 cases-year in women stage I and IV, respectively.
The study showed that early detection through prevention programs is crucial to increase cervical cancer survival.
评估宫颈癌女性的总生存率并描述相关预后因素。
本研究选取了 1999 年至 2004 年间在巴西里约热内卢巴西癌症研究所诊断的 3341 例浸润性宫颈癌病例。收集了临床和病理特征以及随访数据。使用 Kaplan-Meier 曲线进行生存分析，并通过 Cox 模型进行多变量分析。
在所有分析的病例中，68.3%的病例在诊断时为局部晚期疾病。5 年总生存率为 48%。多变量分析后，诊断时的肿瘤分期是唯一与预后显著相关的变量（p<0.001）。死亡率与临床分期之间存在剂量反应关系，分别在 I 期和 IV 期女性中每 1000 例患者-年的死亡率为 27.8 至 749.6 例。
本研究表明，通过预防计划进行早期检测对于提高宫颈癌生存率至关重要。
