Carneiro Saul Rassy, Fagundes Marcela de Araújo, do Rosário Pricila de Jesus Oliveira, Neves Laura Maria Tomazi, Souza Givago da Silva, Pinheiro Maria da Conceição Nascimento
Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, Pará, Brasil.
Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil.
PLoS One. 2017 Nov 16;12(11):e0187579. doi: 10.1371/journal.pone.0187579. eCollection 2017.
Cervical cancer (CC) is the most common type of cancer in women and is the third leading cause of death in most developing countries, causing more than 288,000 deaths in women worldwide each year. The most favourable survival rate is in developed countries, since CC mortality has recently declined in those countries. The purpose of this study was to determine the survival rate and associated factors of CC patients at a reference hospital in the Amazon region. The patient sample included records of 339 patients with cervical cancer who had been hospitalized in Belém, Pará, Brazil from January 2005 to December 2010; the socioeconomic and clinical data were collected between June and September 2016. A survival rate of approximately 84% was observed, and it was found that disease stage (p <0.01), metastasis (p <0.01) and readmission (p <0.01) had significant influences on patient outcome. The impact of these factors on the general survival rate was higher in the Amazon region compared with other regions of Brazil, and the primary survival factors were associated with earlier stages of the disease. However, more national studies are needed on this subject. Our findings may contribute to the development of regional strategies for the prevention of cervical cancer, a reduction in its incidence and mortality rate, an increase in survival time and an improvement in the quality of life of these women.
宫颈癌(CC)是女性中最常见的癌症类型,也是大多数发展中国家女性死亡的第三大主要原因,每年在全球导致超过28.8万名女性死亡。存活率最高的是发达国家,因为这些国家的宫颈癌死亡率最近有所下降。本研究的目的是确定亚马逊地区一家参考医院中宫颈癌患者的存活率及相关因素。患者样本包括2005年1月至2010年12月期间在巴西帕拉州贝伦市住院的339例宫颈癌患者的记录;社会经济和临床数据于2016年6月至9月收集。观察到的存活率约为84%,并且发现疾病分期(p<0.01)、转移(p<0.01)和再次入院(p<0.01)对患者预后有显著影响。与巴西其他地区相比,这些因素对亚马逊地区总体存活率的影响更高,主要存活因素与疾病的早期阶段相关。然而,关于这个主题还需要更多的全国性研究。我们的研究结果可能有助于制定预防宫颈癌的区域策略,降低其发病率和死亡率,延长生存时间并改善这些女性的生活质量。