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晚期宫颈癌女性的生存状况及预测因素

Survival Status and Predictors Among Women with Advanced Stage of Cervical Cancer.

作者信息

Teshome Roza, Yang Irene, Woldetsadik Edom, Girma Eshetu, Higgins Melinda, Wells Jessica

机构信息

Department of Midwifery, School of Nursing & Midwifery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.

出版信息

Int J Womens Health. 2024 Apr 15;16:605-617. doi: 10.2147/IJWH.S455235. eCollection 2024.

Abstract

BACKGROUND

Cervical cancer is one of the leading causes of cancer death in women, even though it is a preventable disease. Most deaths occur in low- and middle-income countries. In addition to early detection and receipt of standard treatments, survivorship is an important component of high quality of care across the cancer continuum.

OBJECTIVE

To assess the survival status of advanced-stage cervical cancer patients after cancer treatment has started.

METHODS AND MATERIALS

A one-year prospective cohort study was employed to assess the survival status of women with advanced stages of cervical cancer. A total of 180 cervical cancer patients were recruited, and the study was conducted from January 10, 2022, to September 20, 2023. Data entry and analysis were done in the SPSS 29 version. Descriptive statistics were used to examine participant characteristics. The Kaplan-Meier procedure and log rank test were used to estimate the duration of survival. Bivariate and multivariate Cox regression analyses were computed for predictor variables with survival status.

RESULTS

Patients receiving cancer treatment at FIGO stages IVA and IVB had survived by 56% and 24%, respectively, whereas patients receiving treatment at stages IIB and IIIA had survived by 100%. The estimated mean survival time at one-year follow-up was 5.706 months (95% CI: 3.785-7.627) for patients with FIGO stage IVB, but 11.537 months (95% CI: 11.199-11.887) for those with stages II and III (P < 0.001). Women over 60 years old had a 1.5-fold higher risk of death than those under 60 (HR: 1.482, P = 0.040).

CONCLUSION

The one-year cumulative survival rate among advanced-stage cervical cancer patients was 77%. Major factors associated with survival were age, cancer stage, the presence of anemia, and waiting time for treatment.

摘要

背景

宫颈癌是女性癌症死亡的主要原因之一,尽管它是一种可预防的疾病。大多数死亡发生在低收入和中等收入国家。除了早期检测和接受标准治疗外,癌症生存者关怀是癌症全程高质量护理的一个重要组成部分。

目的

评估晚期宫颈癌患者开始癌症治疗后的生存状况。

方法和材料

采用为期一年的前瞻性队列研究来评估晚期宫颈癌女性的生存状况。共招募了180例宫颈癌患者,研究于2022年1月10日至2023年9月20日进行。数据录入和分析使用SPSS 29版本。描述性统计用于检查参与者特征。采用Kaplan-Meier法和对数秩检验来估计生存时间。对预测变量与生存状况进行双变量和多变量Cox回归分析。

结果

国际妇产科联盟(FIGO)分期为IVA期和IVB期的接受癌症治疗的患者生存率分别为56%和24%,而IIB期和IIIA期接受治疗的患者生存率为100%。FIGO IVB期患者在一年随访时的估计平均生存时间为5.706个月(95%置信区间:3.785 - 7.627),而II期和III期患者为11.537个月(95%置信区间:11.199 - 11.887)(P < 0.001)。60岁以上女性的死亡风险比60岁以下女性高1.5倍(风险比:1.482,P = 0.040)。

结论

晚期宫颈癌患者的一年累积生存率为77%。与生存相关的主要因素是年龄、癌症分期、贫血的存在以及治疗等待时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd73/11027928/eb71185451a5/IJWH-16-605-g0001.jpg

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