Suppr超能文献

宫颈癌患者的组织学类型特征分析:Inca 医院辅助研究

Characterization of women with cervical cancer assisted at Inca by histological type.

机构信息

Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Auroca. Programa de Saúde Pública e Meio Ambiente. Rio de Janeiro, RJ, Brasil.

Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Auroca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.

出版信息

Rev Saude Publica. 2019 Oct 3;53:88. doi: 10.11606/s1518-8787.2019053001218. eCollection 2019.

Abstract

OBJECTIVE

To determine the distribution of sociodemographic, reproductive, clinical and lifestyle habits in the cohort of women diagnosed with cervical cancer, assisted at Inca between 2012 and 2014, according to the histological type.

METHODS

Retrospective observational study of a hospital cohort of 1,004 women diagnosed with cervical cancer. Data were obtained from the Inca hospital cancer registry, physical and electronic records.

RESULTS

The most frequent histological type was squamous cell carcinoma (83.9%). Approximately 70% of the women aged more than 40 years. The study includes non-white women (67.4%), with less than 8 years of education (51.9%), with onset of sexual activity up to 16 years of age (40.7%), who were pregnant before (95.5%), with more than one pregnancy (82.9%), and more than two children (52.7%); 45.8% of the women were smokers or former smokers. Cervical adenocarcinoma was positively associated with earlier staging (IA-IIA) (OR = 1.79; 95%CI 1.03-3.13), as well as women with ≥ 12 years of education (OR = 6.30; 95%CI 1.97-20,13), who had no children (OR = 3.81; 95%CI 1.20 - 12,08) or who had up to two children (OR = 1.74; 95%CI 1.05 - 2,87).

CONCLUSIONS

The difference between histological types is highlighted, suggesting that women with cervical adenocarcinoma may represent a distinct clinical entity of cervical neoplasia, which may require different approaches from those used in squamous cell carcinoma.

摘要

目的

根据组织学类型,确定 2012 年至 2014 年期间在 Inca 就诊的宫颈癌患者队列中的社会人口学、生殖、临床和生活方式习惯的分布情况。

方法

这是一项回顾性观察性医院队列研究,共纳入 1004 名宫颈癌患者。数据来自 Inca 医院癌症登记处、体格检查和电子记录。

结果

最常见的组织学类型是鳞状细胞癌(83.9%)。约 70%的患者年龄超过 40 岁。该研究包括非白人女性(67.4%),受教育程度低于 8 年(51.9%),性活跃期早至 16 岁(40.7%),95.5%的患者曾怀孕,82.9%的患者怀孕次数多于一次,52.7%的患者育有两个以上子女;45.8%的患者为吸烟者或曾吸烟者。宫颈腺癌与较早的分期(IA-IIA)呈正相关(OR=1.79;95%CI 1.03-3.13),且与受教育程度≥12 年(OR=6.30;95%CI 1.97-20.13)、无子女(OR=3.81;95%CI 1.20-12.08)或育有 1-2 个子女(OR=1.74;95%CI 1.05-2.87)的患者相关。

结论

组织学类型之间存在差异,表明宫颈腺癌患者可能代表一种独特的宫颈肿瘤临床实体,可能需要与鳞状细胞癌不同的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad4d/6776112/b724b0b3701c/1518-8787-rsp-53-88-gf01.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验