释放NOD样和Toll样激动剂作为疫苗佐剂的潜力。
Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants.
作者信息
Maisonneuve Charles, Bertholet Sylvie, Philpott Dana J, De Gregorio Ennio
机构信息
Department of Immunology, University of Toronto, Toronto, ON, Canada M5S 1A8; and.
Novartis Vaccines and Diagnostics, 53100 Siena, Italy.
出版信息
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12294-9. doi: 10.1073/pnas.1400478111. Epub 2014 Aug 18.
Abstract
Innate immunity confers an immediate nonspecific mechanism of microbial recognition through germ line-encoded pattern recognition receptors (PRRs). Of these, Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) have shaped our current understanding of innate regulation of adaptive immunity. It is now recognized that PRRs are paramount in instructing an appropriate adaptive immune response. Their ligands have been the focus of adjuvant research with the goal of generating modern vaccine combinations tailored to specific pathogens. In this review we will highlight the recent findings in the field of adjuvant research with a particular focus on the potential of TLR and NLR ligands as adjuvants and their influence on adaptive immune responses.
摘要
固有免疫通过种系编码的模式识别受体（PRR）赋予一种即时的非特异性微生物识别机制。其中，Toll样受体（TLR）和核苷酸结合寡聚化结构域（NOD）样受体（NLR）塑造了我们目前对适应性免疫固有调节的理解。现在人们认识到，PRR在指导适当的适应性免疫反应中至关重要。它们的配体一直是佐剂研究的重点，目的是生成针对特定病原体的现代疫苗组合。在这篇综述中，我们将重点介绍佐剂研究领域的最新发现，特别关注TLR和NLR配体作为佐剂的潜力及其对适应性免疫反应的影响。
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