Ouédraogo A S, Somé D A, Dakouré P W H, Sanon B G, Birba E, Poda G E A, Kambou T
Laboratoire de Bactériologie-virologie, CHU Souro Sanou, Bobo Dioulasso, Burkina Faso.
Med Trop (Mars). 2011 Feb;71(1):49-52.
The purpose of this study was to evaluate the bacterial profile and antimicrobial susceptibility of surgical site infection (SSI) as a basis for optimizing probabilistic antibiotherapy.
A 6-month transversal retrospective study was carried out at the Souro Sano Hospital Laboratory from November 1st, 2006 to April 30th, 2007. All positive pus samples collected for etiologic diagnosis of SSI were included.
In a series of 681 patients who underwent surgery at the hospital, SSI was observed in 159 cases for an incidence of 23.4%. Pus samples for etiologic diagnosis were collected from 112 patients and led to identification of 103 bacterial strains. The most common strains were enterobacteriaceae in 54.0%, gram-positive cocci in 29.0% and non-fermenting Gram-negative bacilli in 16.5%. Escherichia coli was the most common species (30%) followed by Staphylococcus aureus (16.5%) and Pseudomonas aeroginosa (12.0%). Enterobacteriaceae resistance rates were 71% to amoxicillin, 64% to clavulanic acid-amoxicillin and 15% to third generation cephalosporin. Most S. aureus isolates (85%) were sensitive to methicillin. Non-fermenting Gram-negative bacilli resistance rates were 68.5% to carboxypenicillin and 56% to fluoroquinolones.
These findings indicate that SSI can be treated using third generation cephalosporin-aminosides in combination with oral fluoroquinolones.
本研究旨在评估手术部位感染（SSI）的细菌谱及抗菌药敏情况，为优化经验性抗菌治疗提供依据。
于2006年11月1日至2007年4月30日在Souro Sano医院实验室进行了一项为期6个月的横向回顾性研究。纳入所有为进行SSI病因诊断而采集的阳性脓液样本。
在该医院接受手术的681例患者中，观察到159例SSI，发生率为23.4%。从112例患者中采集了用于病因诊断的脓液样本，共鉴定出103株细菌。最常见的菌株为肠杆菌科细菌，占54.0%；革兰氏阳性球菌，占29.0%；非发酵革兰氏阴性杆菌，占16.5%。大肠埃希菌是最常见的菌种（30%），其次是金黄色葡萄球菌（16.5%）和铜绿假单胞菌（12.0%）。肠杆菌科细菌对阿莫西林的耐药率为71%，对克拉维酸 - 阿莫西林的耐药率为64%，对第三代头孢菌素的耐药率为15%。大多数金黄色葡萄球菌分离株（85%）对甲氧西林敏感。非发酵革兰氏阴性杆菌对羧苄青霉素的耐药率为68.5%，对氟喹诺酮类的耐药率为56%。
这些研究结果表明，SSI可采用第三代头孢菌素 - 氨基糖苷类药物联合口服氟喹诺酮类药物进行治疗。
