Interfaculty Institute of Microbiology & Infection Medicine, Cellular & Molecular Microbiology Section, University of Tübingen, Germany.
Future Microbiol. 2011 May;6(5):489-93. doi: 10.2217/fmb.11.37.
The human anterior nares are used by Staphylococcus aureus as the major colonization site in 20-30% of the human population. Eradication of S. aureus carriage can significantly reduce the numbers of nosocomial infections. However, the interactions governing the colonization process have remained elusive and it has been debated whether S. aureus adopts a biofilm-like state in the nose. We summarize recent studies on staphylococcal living conditions during nasal colonization, which favour a dispersed rather than a biofilm-related mode of growth during S. aureus nasal colonization. This notion is of major importance for future directions in the development of new decolonization strategies.
金黄色葡萄球菌（Staphylococcus aureus）常定植于人鼻腔的前鼻道，20-30%的人群携带该菌。消除金黄色葡萄球菌定植可显著降低医院获得性感染的发生。然而，定植过程中的相互作用仍不清楚，且金黄色葡萄球菌是否在鼻腔中呈生物膜样状态一直存在争议。我们总结了近期关于金黄色葡萄球菌在鼻腔定植时生存条件的研究，这些研究表明金黄色葡萄球菌在鼻腔定植时更倾向于分散生长，而非生物膜样生长。这一观点对未来开发新的去定植策略具有重要意义。
