Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Lublin, Poland.
Acta Obstet Gynecol Scand. 2011 Dec;90(12):1402-5. doi: 10.1111/j.1600-0412.2011.01189.x. Epub 2011 Jun 16.
To compare the prevalence of human papillomavirus (HPV) in placentas from women with spontaneous abortions and from control women after term delivery.
Cross-sectional study.
Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin (Poland).
Patients whose spontaneous abortions occurred between the 6th and the 16th week of pregnancy (n=51), and women after term delivery (n=78).
Polymerase chain reaction (PCR).
HPV DNA prevalence rate and the fraction of HPV 16/18 infections in aborted products of conception and placentas.
Patients with spontaneous abortion did not differ from the controls in terms of mean age and the fraction of primiparas. The DNA of HPV was detected in 17.7% of aborted products of conception and in 24.4% of placentas from term deliveries. The aborted products of conception and full-term placentas were positive for HPV 16/18 in 11.8 and 12.8% cases, respectively. Patients whose material was positive for HPV DNA or those with confirmed HPV 16/18 did not differ significantly from HPV-negative women in terms of mean age and the fraction of primiparas.
The HPV 16/18 infection rate does not seem be higher in cases of spontaneous abortions. Nevertheless, further study of the consequences of HPV infection in pregnancy is still needed.
比较自发性流产和足月分娩后妇女胎盘中人乳头瘤病毒（HPV）的流行率。
横断面研究。
波兰卢布林医科大学妇产科和妊娠病理学系。
6 至 16 孕周自发性流产患者（n=51）和足月分娩后妇女（n=78）。
聚合酶链反应（PCR）。
流产产物和胎盘 HPV DNA 阳性率及 HPV 16/18 感染率。
与对照组相比，流产患者的平均年龄和初产妇比例无差异。HPV DNA 在 17.7%的流产产物和 24.4%的足月胎盘中被检出。HPV 16/18 在 11.8%的流产产物和 12.8%的足月胎盘中呈阳性。HPV DNA 阳性患者或 HPV 16/18 阳性患者与 HPV 阴性妇女在平均年龄和初产妇比例方面无显著差异。
自发性流产中 HPV 16/18 感染率似乎没有升高。然而，仍需要进一步研究 HPV 感染在妊娠中的后果。
