Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Dev Growth Differ. 2011 May;53(4):576-86. doi: 10.1111/j.1440-169X.2011.01271.x.
The Dictyostelium model has a set of features uniquely well-suited to developing our understanding of transcriptional control. The complete Dictyostelium discoideum genome sequence has revealed that many of the molecular components regulating transcription in larger eukaryotes are conserved in Dictyostelium, from transcription factors and chromatin components to the enzymes and signals that regulate them. In addition, the system permits visualization of single gene firing events in living cells, which provides a more detailed view of transcription and its relationships to cell and developmental processes. This review will bring together the available knowledge of the structure and dynamics of the Dictyostelium nucleus and discuss recent transcription imaging studies and their implications for stability and accuracy of cell decisions.
纤毛菌模型具有一系列独特的特征，非常适合我们深入了解转录控制。完整的盘基网柄菌基因组序列表明，调节较大真核生物转录的许多分子成分在纤毛菌中是保守的，从转录因子和染色质成分到调节它们的酶和信号。此外，该系统允许在活细胞中可视化单个基因的激活事件，从而更详细地观察转录及其与细胞和发育过程的关系。这篇综述将汇集纤毛菌核结构和动力学的现有知识，并讨论最近的转录成像研究及其对细胞决策的稳定性和准确性的影响。
