Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.
UCL Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Cells. 2021 Nov 5;10(11):3036. doi: 10.3390/cells10113036.
The social amoeba provides an excellent model for research across a broad range of disciplines within biology. The organism diverged from the plant, yeast, fungi and animal kingdoms around 1 billion years ago but retains common aspects found in these kingdoms. has a low level of genetic complexity and provides a range of molecular, cellular, biochemical and developmental biology experimental techniques, enabling multidisciplinary studies to be carried out in a wide range of areas, leading to research breakthroughs. Numerous laboratories within the United Kingdom employ as their core research model. This review introduces and then highlights research from several leading British research laboratories, covering their distinct areas of research, the benefits of using the model, and the breakthroughs that have arisen due to the use of as a tractable model system.
粘菌为生物学的众多领域提供了一个极好的模型，用于开展跨学科的研究。该生物大约在 10 亿年前与植物、酵母、真菌和动物王国分道扬镳，但保留了这些王国中常见的特征。粘菌的遗传复杂性较低，并提供了一系列分子、细胞、生化和发育生物学实验技术，使多学科研究能够在广泛的领域中进行，从而取得研究突破。英国的许多实验室都将其作为核心研究模型。本综述介绍了粘菌，然后重点介绍了来自几个英国领先研究实验室的研究成果，涵盖了它们各自的研究领域、使用该模型的好处，以及由于将其作为一种易于处理的模型系统而产生的突破。
