General Directorate of Mother and Child Health and Family Planning, Ministry of Health of Turkey, Ankara, Turkey.
BJOG. 2011 Sep;118(10):1216-22. doi: 10.1111/j.1471-0528.2011.03002.x. Epub 2011 May 18.
To review the clinical and demographic characteristics of pregnant and postpartum women who died as a consequence of influenza A H1N1 (2009) infection in Turkey.
A review of the records for pregnant and postpartum women who died as a consequence of H1N1 influenza virus infection.
Nationwide in Turkey.
Thirty-six pregnant or postpartum women who died as a result of confirmed pandemic H1N1 influenza virus infection.
Using the General Directorate of Mother and Child Health and Family Planning (MCHFP) Registry of the Ministry of Health of Turkey, we identified all pregnant and postpartum women who died as a result of confirmed influenza A H1N1 (2009) infection between 29 October and 31 December 2009.
Maternal mortality as a result of H1N1 virus infection.
The average time from symptom onset to initial presentation for health care was approximately 2.5 days, and the mean time from symptom onset to the receipt of antiviral medication was approximately 5.5 days. Only one-fifth of all women received early antiviral treatment (administered 2 days or less after symptom onset) and only one woman was vaccinated for H1N1 influenza 1 week before the onset of symptoms. The cause-specific maternal mortality ratio for H1N1 influenza infection in Turkey was estimated to be 3.01. The calculated risk of death associated with H1N1 influenza virus infection was approximately four times higher in pregnant and postpartum women than in the general population (relative risk, 3.88; 95% confidence interval, 2.77-5.43).
Pregnant women are at increased risk for complications of, and death from, H1N1 influenza infection. Prompt evaluation and antiviral treatment of influenza-like illness should be considered in such women. Vaccination for H1N1 influenza may reduce the total number of deaths in pregnant and postpartum women. The high cause-specific maternal mortality rate suggests that H1N1 influenza virus infection may have increased the 2009 maternal mortality ratio in Turkey.
回顾在土耳其，因感染甲型 H1N1（2009 年）流感而死亡的孕妇和产后妇女的临床和人口统计学特征。
对因感染 H1N1 流感病毒而死亡的孕妇和产后妇女的记录进行回顾。
土耳其全国。
36 名因确诊大流行 H1N1 流感病毒感染而死亡的孕妇或产后妇女。
利用土耳其卫生部母婴健康和计划生育总局（MCHFP）登记处，我们确定了所有在 2009 年 10 月 29 日至 12 月 31 日期间因确诊的甲型 H1N1（2009 年）流感感染而死亡的孕妇和产后妇女。
因 H1N1 病毒感染导致的孕产妇死亡率。
从症状出现到首次就诊的平均时间约为 2.5 天，从症状出现到接受抗病毒药物治疗的平均时间约为 5.5 天。只有五分之一的妇女接受了早期抗病毒治疗（症状出现后 2 天或更短时间内给药），只有一名妇女在症状出现前一周接种了 H1N1 流感疫苗。土耳其因 H1N1 流感感染导致的特定病因孕产妇死亡率估计为 3.01。与普通人群相比，感染 H1N1 流感病毒的孕妇和产后妇女的死亡风险增加了约 4 倍（相对风险，3.88；95%置信区间，2.77-5.43）。
孕妇感染 H1N1 流感后发生并发症和死亡的风险增加。应考虑对有流感样症状的孕妇进行及时评估和抗病毒治疗。接种 H1N1 流感疫苗可能会降低孕妇和产后妇女的总死亡人数。高特定病因孕产妇死亡率表明，H1N1 流感病毒感染可能导致 2009 年土耳其孕产妇死亡率增加。
