Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2230, USA.
Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1061-3. doi: 10.1158/1055-9965.EPI-11-0247. Epub 2011 May 17.
Growing body of evidence implicates human cytomegalovirus (HCMV) in the etiology of glioblastoma (GBM). Although HCMV is a ubiquitous herpesvirus, only a minority of those infected develop GBM, suggesting the involvement of host genetic factors in susceptibility to HCMV-induced/spurred GBM. HCMV has evolved a large repertoire of strategies for decreasing the efficacy of the host immune response and interfering with viral clearance. One strategy involves the generation of proteins that have functional properties of the Fcgamma receptor (FcγR), which may enable the virus to evade host immunosurveillance by avoiding the effector consequences of antibody binding, such as antibody-dependent cellular cytotoxicity. Results of binding studies involving HCMV-encoded FcγR and genetically different immunoglobulin G proteins suggest that GM genes--genetic determinants of immunoglobulin γ chains--could modulate this viral strategy and thus serve as functional risk factors for the development of GBM, potentially unifying its seemingly disparate infectious, immune, and genetic etiologies.
越来越多的证据表明人类巨细胞病毒（HCMV）与胶质母细胞瘤（GBM）的病因有关。尽管 HCMV 是一种普遍存在的疱疹病毒，但只有少数感染者会发展为 GBM，这表明宿主遗传因素在易感性方面起作用 HCMV 诱导/刺激 GBM。HCMV 已经进化出了大量的策略来降低宿主免疫反应的有效性并干扰病毒清除。一种策略涉及生成具有 Fcγ 受体（FcγR）功能特性的蛋白质，这可能使病毒通过避免抗体结合的效应后果，如抗体依赖性细胞毒性，从而逃避宿主免疫监视。涉及 HCMV 编码的 FcγR 和遗传上不同的免疫球蛋白 G 蛋白的结合研究结果表明，GM 基因——免疫球蛋白 γ 链的遗传决定因素——可能调节这种病毒策略，从而作为 GBM 发展的功能性风险因素，潜在地统一其看似不同的感染、免疫和遗传病因。
