Department of Internal Medicine, School of Medicine, University of Campinas, Campinas, Brazil.
J Endocrinol Invest. 2011 Oct;34(9):680-4. doi: 10.3275/7725. Epub 2011 May 17.
This report investigated the relationship between anthropometric measurements of body fat distribution and lipid response to statins in hypercholesterolemic hypertensive patients.
We prospectively examined 129 subjects who used either simvastatin 20 mg/day (no.=83) or atorvastatin 10 mg/day (no.=46) for 3 months. Anthropometry included evaluation of body mass index, waist and hip circumferences, and waist-to-hip-ratio.
Significant decreases in LDL (p<0.001), total cholesterol (p<0.001), and triglycerides (p=0.04) levels were detected after 3 months of therapy in the whole sample. At baseline, only an inverse correlation between waist circumference and HDLcholesterol levels was detected (r=-0.18; p=0.04). Conversely, a direct relationship between hip circumference and HDLcholesterol response to statins was found in the whole sample (r=0.24; p=0.006), while no other anthropometric measurement displayed significant correlation with lipid changes. The association between HDL-cholesterol response and hip circumference was further confirmed by stepwise regression analysis adjusted for baseline HDL-cholesterol levels, metabolic syndrome, body mass index, and waist circumference.
Hip circumference, a surrogate marker of peripheral adiposity, is associated with HDL-cholesterol changes following statin therapy in hypertensive patients.
本报告研究了肥胖分布的人体测量学指标与高胆固醇血症高血压患者他汀类药物治疗后血脂反应之间的关系。
我们前瞻性地检查了 129 名使用辛伐他汀 20mg/天（n=83）或阿托伐他汀 10mg/天（n=46）治疗 3 个月的患者。人体测量学包括评估体重指数、腰围和臀围以及腰臀比。
在整个样本中，治疗 3 个月后 LDL（p<0.001）、总胆固醇（p<0.001）和甘油三酯（p=0.04）水平显著降低。在基线时，仅检测到腰围与 HDL 胆固醇水平呈负相关（r=-0.18；p=0.04）。相反，在整个样本中发现臀围与他汀类药物治疗后 HDL 胆固醇反应呈直接相关（r=0.24；p=0.006），而其他人体测量指标与血脂变化无显著相关性。通过调整基线 HDL 胆固醇水平、代谢综合征、体重指数和腰围的逐步回归分析进一步证实了 HDL 胆固醇反应与臀围之间的关联。
臀围，外周肥胖的替代标志物，与高血压患者他汀类药物治疗后 HDL 胆固醇的变化相关。
