Treglia G, Taralli S, Giordano A
Institute of Nuclear Medicine, Department of Bioimages and Radiological Sciences, Catholic University of the Sacred Heart, Rome, Italy.
Sarcoidosis Vasc Diffuse Lung Dis. 2011 Oct;28(2):87-94.
This study was designed to systematically review the emerging role of whole-body positron emission tomography (PET) with 18F-Fluorodeoxyglucose (FDG) in patients with sarcoidosis.
A comprehensive literature search of published studies through December 2010 in PubMed/MEDLINE and Embase databases regarding whole-body FDG-PET and PET/CT in patients with sarcoidosis was performed.
Ultimately, we identified nine studies comprising a total of 379 patients with sarcoidosis. Main findings of the included studies are presented.
from this systematic review we can summarize that: (1) positive FDG-PET findings should be interpreted with caution in differentiating sarcoidosis from other inflammatory diseases and malignant abnormalities; (2) FDG-PET seems to be a very useful molecular imaging method in assessing disease activity, in staging and identifying occult sites, and in monitoring treatment response in patients with sarcoidosis; (3) FDG-PET shows a better diagnostic accuracy compared to 67Ga scintigraphy in patients with sarcoidosis, because of a better sensitivity of FDG-PET (mainly due to the high quality of FDG-PET images with superior contrast and spatial resolution compared to 67Ga scintigraphy) in addition to several practical advantages (less radiation exposure, shorter time between injection and imaging).
本研究旨在系统评价18F-氟脱氧葡萄糖（FDG）全身正电子发射断层扫描（PET）在结节病患者中的新作用。
通过检索PubMed/MEDLINE和Embase数据库中截至2010年12月发表的关于结节病患者全身FDG-PET和PET/CT的研究进行全面文献检索。
最终，我们确定了9项研究，共纳入379例结节病患者。呈现了纳入研究的主要发现。
通过该系统评价我们可以总结出：（1）在鉴别结节病与其他炎症性疾病和恶性病变时，FDG-PET阳性结果的解读应谨慎；（2）FDG-PET似乎是评估结节病患者疾病活动度、分期、识别隐匿部位及监测治疗反应的一种非常有用的分子成像方法；（3）与67Ga闪烁扫描相比，FDG-PET在结节病患者中显示出更好的诊断准确性，这是因为FDG-PET具有更高的敏感性（主要是由于与67Ga闪烁扫描相比，FDG-PET图像质量更高，具有更好的对比度和空间分辨率）以及一些实际优势（辐射暴露更少、注射与成像之间的时间更短）。
