Fu Hong Hai, Zhuang Qian Wei, He Jie, Wang Li Zhen, He Yue
Departments of Oral and Maxillofacial Surgery, School of Medicine, Shanghai Jiao-tong University, Shanghai Ninth People's Hospital, Shanghai, China.
J Craniofac Surg. 2011 May;22(3):1136-9. doi: 10.1097/SCS.0b013e3182108fbf.
Giant cell-rich osteosarcoma (GCRO) is a rare subtype of osteosarcoma, and no literature has reported occurrence in the mandible region up to now. In this article, we report a case of GCRO originating from the mandible in a 67-year-old woman who presented a history of painless mass located in the left side of the mandible after teeth extraction. The curettage biopsy histologic diagnosis is giant cell reparative granuloma before mandibulectomy surgery, but panoramic radiograph revealed an osteolytic lesion. The tumor was completely resected with segmental mandibulectomy and soft tissue with postoperative histologic diagnosis of GCRO. The free fibula osteomyocutaneous flap was performed to reconstruct the defect of the mandible and gingival mucosa. The patient received postoperative radiotherapy and chemotherapy. The 1-year follow-up situation is fine.
富含巨细胞的骨肉瘤（GCRO）是骨肉瘤的一种罕见亚型，迄今为止尚无文献报道其发生于下颌骨区域。在本文中，我们报告了一例源自下颌骨的GCRO病例，患者为一名67岁女性，拔牙后左侧下颌骨出现无痛性肿块。刮除活检组织学诊断为巨细胞修复性肉芽肿，在行下颌骨切除术之前，全景X线片显示为溶骨性病变。肿瘤通过下颌骨节段性切除术和软组织完全切除，术后组织学诊断为GCRO。采用游离腓骨骨肌皮瓣修复下颌骨和牙龈黏膜缺损。患者接受了术后放疗和化疗。1年随访情况良好。
