超重韩国成年人中人类腺病毒-36 的相关性。

Association of human adenovirus-36 in overweight Korean adults.

机构信息

Department of Biotechnology, The Catholic University of Korea, Korea.

出版信息

Int J Obes (Lond). 2012 Feb;36(2):281-5. doi: 10.1038/ijo.2011.102. Epub 2011 May 17.

DOI:10.1038/ijo.2011.102

PMID:21587203

Abstract

BACKGROUND

Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults.

METHODS

A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23 ≤ BMI<25 kg m(-2) and obese subjects were those with BMI ≥ 25 kg m(-2), according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay.

RESULTS

Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67).

CONCLUSION

Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults.

摘要

背景

虽然人类腺病毒-36（Ad-36）已被报道与美国成年人和儿童肥胖有关，但在韩国儿童和意大利人群中，与荷兰或比利时人群或美国军人中均未发现这种关联。因此，我们研究了腺病毒-36 感染是否与韩国成年人肥胖有关。

方法

共选取 540 名年龄和性别匹配的个体，他们来自于在 Ewha Womans 大学医疗中心进行常规健康检查的参与者。超重参与者的定义为体质指数（BMI）为 23≤BMI<25kgm(-2)的个体，肥胖者的 BMI 则≥25kgm(-2)，按照国际肥胖工作组的定义。使用血清中和试验测量 Ad-36 抗体。

结果

尽管超重参与者中 Ad-36 抗体阳性的比例高于正常体重或肥胖参与者（分别为 40%、32.8%和 30%），但差异无统计学意义。在三组中，Ad-36 抗体阳性的参与者甘油三酯（TG）水平较低，肥胖组总胆固醇（TC）水平较高，正常和肥胖组高密度脂蛋白胆固醇（HDL-C）水平较高。校正年龄、性别和腰围后，Ad-36 抗体阳性与超重的比值比（OR）大于正常体重（OR=2.03；95%置信区间（CI），1.16-3.55）。然而，在肥胖组，这种 OR 无统计学意义（OR=1.56；95%CI，0.67-3.67）。