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N-苄基-2-(3-氯-4-羟基苯基)乙酰胺

N-Benzyl-2-(3-chloro-4-hy-droxy-phen-yl)acetamide.

作者信息

Davis Rohan A, Healy Peter C

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 8;66(Pt 10):o2521. doi: 10.1107/S1600536810035397.

DOI:10.1107/S1600536810035397
PMID:21587515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2983291/
Abstract

The title compound, C(15)H(14)ClNO(2), was synthesized as part of a project to generate a combinatorial library based on the fungal natural product 2-(3-chloro-4-hy-droxy-phen-yl)acetamide. It crystallizes as non-planar discrete mol-ecules [the peripheral 3-chloro-4-hy-droxy-phenyl and benzyl groups are twisted out of the plane of the central acetamide group, with N-C-C-C and C-C-C-C torsion angles of -58.8 (3) and 65.0 (2)°, respectively] linked by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.

摘要

标题化合物C(15)H(14)ClNO(2)是作为基于真菌天然产物2-(3-氯-4-羟基苯基)乙酰胺生成组合文库项目的一部分而合成的。它以非平面离散分子形式结晶[外围的3-氯-4-羟基苯基和苄基扭转出中心乙酰胺基团的平面，N-C-C-C和C-C-C-C扭转角分别为-58.8 (3)°和65.0 (2)°]，通过分子间N-H⋯O和O-H⋯O氢键相连。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f03/2983291/78d71155c9c3/e-66-o2521-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f03/2983291/24001f59b05c/e-66-o2521-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f03/2983291/78d71155c9c3/e-66-o2521-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f03/2983291/24001f59b05c/e-66-o2521-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f03/2983291/78d71155c9c3/e-66-o2521-fig2.jpg

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