Chinet A E
Département de physiologie de l'université, CMU, Genève, Suisse.
Reprod Nutr Dev. 1990;30(1):1-11.
Attempts to predict and to measure the energy cost of ionic homeostasis in tissue cells are briefly reviewed and attention is drawn to the importance of ion-flux--as well as ion-gradient--maintenance for the preservation of cell structure and function. The energetic consequences of acute and chronic adjustments of two primary-active transport processes, Na-K transport across plasma(sarco) lemma and Ca transport across the endo(sarco)plasmic-reticular membrane, are illustrated. The question of the contribution of protein turnover to the energy expenditure of cell maintenance is raised, but not answered. After looking back on the now well-established concepts of the "intrinsic" cellular control of energy expenditure and the so-called "extrinsic" cellular control by intracellular calcium ion activities, it is suggested that the organ may also control cell metabolism under non-ischemic conditions, through heterogeneous distribution of arterial blood and erythrocytes to cells.
本文简要回顾了预测和测量组织细胞中离子稳态能量成本的尝试，并强调了维持离子通量和离子梯度对保持细胞结构和功能的重要性。文中阐述了两种主要主动运输过程（即钠钾跨质膜（肌膜）运输和钙跨内质网（肌质网）膜运输）急性和慢性调节的能量后果。文中提出了蛋白质周转对细胞维持能量消耗贡献的问题，但未给出答案。在回顾了现已确立的关于能量消耗的“内在”细胞控制概念以及细胞内钙离子活性的所谓“外在”细胞控制概念之后，本文提出，在非缺血条件下，器官也可能通过动脉血和红细胞向细胞的不均匀分布来控制细胞代谢。
